Multi-region chewing gum composition including isomalt gum region

ABSTRACT

The present invention relates to chewing or bubble gum compositions that include a first region composition and a second, or gum, region adjacent to or surrounding the first region. The first region composition may be a center-fill composition, such as a liquid-fill composition. The second region includes a polyol composition including isomalt alone or in combination with other polyols. The addition of isomalt to the second region provides stability to the chewing gum composition and reduces the problem of leaking and migration of the first region composition into the second region. The multi-region chewing gum composition also may include a coating region which surrounds or covers the second region.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation-in-part of U.S. patent applicationSer. No. 11/410,962, filed Apr. 25, 2006, which claims the benefit ofU.S. Provisional Application No. 60/776,637, filed Feb. 24, 2006, andU.S. Provisional Application No. 60/683,634, filed May 23, 2005, andU.S. patent application Ser. No. 11/410,962 is a continuation-in-part ofU.S. patent application Ser. No. 11/210,954, filed on Aug. 24, 2005,which is a continuation-in-part of U.S. patent application Ser. No.10/925,822, filed Aug. 25, 2004, the contents all of which areincorporated herein by reference.

FIELD

The present invention includes compositions for multi-region chewing gumproducts. In particular, the individual chewing gum pieces include afirst region surrounded by a second, or gum, region and the secondregion includes isomalt alone or in combination with other polyols.

BACKGROUND

Liquid or center-filled gum and other confectionery products are inpopular demand today. Typically, these products have a solid exteriorportion and a soft or liquid-type center. The outer portion can bechewing gum or bubble gum of some type, while the liquid center portioncan be a flavored material typically having a syrup-like consistency.

There has been a difficulty in preparing some center-filled products,however. It has been found that certain center-fill compositions tend toleak and migrate. The center-fill compositions tend to be absorbed intothe chewing gum region. This is particularly problematic inliquid-filled chewing gum compositions. The problem of migration isespecially evident when certain polyols, such as sorbitol, are used inthe chewing gum region. For instance, sorbitol has a high porosity, andthus, readily absorbs liquid from the center-fill composition.

There is a need for new gum compositions, and particularly hard orcrunchy coated gums, which provide the desired hard shell coating layerin combination with a multi-region, such as a center-filled, gum, whileresisting loss of liquidity. There is also a need for a multi-regiongum, which retains its liquid region composition during manufacturingand during its shelf-life, and which can be made in a reduced piece-sizewithout loss of the liquid-region properties.

SUMMARY

It has been found that by adding isomalt to the second, or gum, regionof the product, greater stability can be achieved, thus lessening theproblems of leaking and migration of the center-fill composition(including migration of hydrophobic and hydrophilic components). Isomaltpossesses a variety of characteristics that provide advantages for usein the gum region of multi-region, such as center-fill, gum. Inparticular, isomalt's particle size, particle surface area,water-solubility and moisture-sorption characteristics make it desirablefor use in such chewing gum compositions. The inclusion of isomalt inthe gum region, either alone or in combination with other polyols,provides shelf-life stability due to reduced absorption of otherregions, such as a center-fill region, into the gum region, as well asdimensional stability and seal integrity in the machined chewing gumpieces. Dimensional stability and seal integrity allow for machinabilityof smaller chewing gum pieces than in the past.

In some embodiments, there is provided a multi-region chewing gumcomposition including a first region composition and a second regioncomposition adjacent to the first region composition, the second regionincluding an elastomer and a polyol composition including isomalt aloneor in combination with at least a second polyol.

Some embodiments provide a center-fill chewing gum composition includinga center-fill composition and a gum region composition surrounding thecenter-fill composition, the gum region composition including a gum baseand a polyol composition including isomalt alone or in combination withat least a second polyol.

Some embodiments provide a center-fill chewing gum composition includinga liquid center-fill composition and a gum region surrounding thecenter-fill composition, the gum region including an elastomer and apolyol composition including isomalt in amounts of about 75% to about100% by weight of the polyol composition and sorbitol in amounts ofabout 0% to about 25% by weight of the polyol composition.

Some embodiments provide a method of preparing a multi-region chewinggum composition, which includes the steps of:

(a) extruding a multi-region composition including a first regioncomposition and a second region composition adjacent to the first regioncomposition, the second region composition including:

-   -   (i) an elastomer; and    -   (ii) a polyol composition including isomalt alone or in        combination with at least a second polyol;

(b) sizing the multi-region composition;

(c) feeding the multi-region composition into a forming mechanism;

(d) forming individual pieces of the multi-region composition; and

(e) coating the individual pieces with a coating.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a perspective showing of a typical gum slab of the typeemployed in some embodiments.

FIGS. 2 and 3 show two arrangements for edge shapes of the slab of FIG.1.

FIG. 4 is a schematic cross-sectional showing of the slab of FIG. 1.

DETAILED DESCRIPTION

In some embodiments there is a multi-region chewing gum composition thatincludes a first region composition and a second region compositionadjacent to the first region composition. For instance, the first regioncomposition may be a center-fill composition and the second regioncomposition may be a gum region surrounding the center-fill. The firstregion composition may be a liquid composition, and may includecomponents, such as flavors, sweeteners and the like. The second regioncomposition includes an elastomer and a polyol composition includingisomalt alone or in combination with at least a second polyol, such as,for example, sorbitol.

Isomalt is disaccharide alcohol. Isomalt can be prepared byhydrogenating isomaltulose. Products of the hydrogenation can include6-O-α-D-glucopyranosyl-D-sorbitol(1,6-GPS);1-O-α-D-glucopyranosyl-D-sorbitol(1,1-GPS);1-O-α-D-glucopyranosyl-D-mannitol(1,1-GPM);6-O-α-D-glucopyranosyl-D-mannitol(1,6-GPM); and mixtures thereof. Somecommercially available isomalt materials include an almost equimolarmixture of 1,6-GPS, and 1,1-GPM. Other isomalt materials can includepure 1,6-GPS; 1,1-GPS; 1,6-GP; and 1,1-GPM. Still other isomaltmaterials can include mixtures of 1,6-GPS; 1,1-GPS; 1,6-GPM; and 1,1-GPMat any ratio.

As mentioned above, the inclusion of isomalt in the second regioncomposition of multi-region chewing gum provides stability to thechewing gum. Isomalt possess a number of advantageous characteristicsfor use in the second region of multi-region chewing gum, includingparticle size, surface area and water-solubility, among others. Ingeneral, the particle size of isomalt used in the second region may beabout 15 to about 100 microns, more specifically about 15 to about 70microns, and even more specifically about 20 to about 50 microns. Theseparticles sizes are substantially lower than conventionally usedpolyols, which typically have particle sizes of much greater than 100microns. The surface area of isomalt used in the gum region may be about0.5 m²/g. Additionally, the solubility of isomalt in water is less than35% at 30° C. In contrast, the solubility of maltitol in water is about60% at 30° C. The low water-solubility of isomalt prevents itssolubilization during processing, thereby adding to the improveddimensional stability of the manufactured chewing gum pieces.

In some embodiments, isomalt may be present in amounts of about 60% toabout 100% by weight of the polyol composition, more specifically about75% to about 100% by weight of the polyol composition. Additionalpolyols may be included in the polyol composition, such as, but notlimited to, sorbitol, maltitol, erythritol, xylitol, mannitol, lactitoland combinations thereof. In some embodiments, for instance, the polyolcomposition includes about 50% to about 100% by weight isomalt and about0% to about 50% by weight sorbitol. In some other embodiments, thepolyol composition includes about 75% to about 100% by weight isomaltand about 0% to about 25% by weight sorbitol. The ratio of isomalt tosorbitol in the polyol composition may be about 3:2 to about 4:1 in someembodiments. In some embodiments including isomalt and sorbitol, isomaltmay have a particle size as described above and sorbitol may have aparticle size of about 200 to about 250 microns.

In addition to isomalt, syrups also may be added to the second region.Syrups may include hydrogenated starch hydrolystates, particularlyLycasin®. The syrup may also include sugars, triacetin, lectithin, andpolyols such as hydrogenated starch hydrolysates, sorbitol, maltitol,glycerin, and combinations thereof.

In some embodiments, the syrup may act to saturate the polyolcomposition in the second region, thereby reducing the tendency of thefirst region composition to be absorbed into the second region. Suchsyrups may be present in amounts of about 1% to about 15% by weight ofthe chewing gum composition, more specifically about 3% to about 12% byweight, and even more specifically about 9% to about 12% by weight insome embodiments.

In some embodiments including a syrup, the ratio of the polyolcomposition to the syrup is about 15:1 to about 4:1 in the gum region.More specifically, in some embodiments the ratio of the polyolcomposition to the syrup is about 8:1 to about 6:1.

The multi-region chewing gum compositions described herein exhibitimproved dimensional stability and more robust seals as compared toconventional chewing gum compositions. The improved machinability of thechewing gum compositions allows for the manufacturing of smallermulti-region gum pieces than with prior chewing gum compositions. Forinstance, the chewing gum compositions described herein can be used toform multi-region gum pieces having an individual piece weight of about1.2 g as opposed to weights of about 1.6 g or higher. Accordingly, insome embodiments, the chewing gum pieces may have an individual pieceweight of about 1.2 g to about 1.6 g. Smaller gum pieces arecommercially desirable and additionally have been found to coat moreuniformly than larger, conventional center-fill gum pieces.

In some embodiments, multi-region chewing gums can include multi-layergums such as three-layer gums in which the center layer has a firstsurface in contact with a first gum layer and a second surface incontact with a second gum layer. Incorporation of isomalt into one orboth of the chewing gum layers, as described herein, may be desirable toprevent, or at least reduce, migration of the center-layer compositioninto the two gum layers. Moreover, reducing such migration may bedesirable to maintain the distinct characteristics, such as the texturesor flavors, of each separate layer. In some embodiments, migration ofthe hydrophilic and/or hydrophobic components contained in thecenter-layer composition is reduced. For instance, it may be desirableto reduce migration of water and/or oils contained in the center-layercomposition, which, in addition to affecting the stability of thechewing gum piece, may affect the characteristics of the chewing gumlayers. Barrier layers also may be used in some embodiments to assist inreducing migration of the center-layer composition, such as described inassignee's co-pending U.S. application Ser. No. 11/411,543, filed onApr. 26, 2006.

As used herein the transitional term “comprising,” (also “comprises,”etc.) which is synonymous with “including,” “containing,” or“characterized by,” is inclusive or open-ended and does not excludeadditional, unrecited elements or method steps, regardless of its use inthe preamble or the body of a claim.

As used herein, the terms “bubble gum” and “chewing gum” are usedinterchangeably and are both meant to include any gum compositions.

As used herein, the terms “first region” or “center-fill” refer to theinnermost region of the compositions. These terms do not imply symmetryof a gum piece, only that the “first region” or “center-fill” isadjacent to or within another region of the gum piece. In someembodiments, more than one center-fill may be present.

As used herein, the terms “second region” and “gum region” refer to aregion of the compositions that may be adjacent to or at least partiallysurrounding the center-fill, or first, region.

As used herein, the term “coating” is used to refer to the outermostregion of the compositions. The term “coating” can include particulateor non-particulate compositions.

As used herein, the terms “surround,” “surrounding,” and the like arenot limited to encircling. These terms may refer to enclosing orconfining on all sides, encircling or enveloping, and are not limited tosymmetrical or identical thicknesses for a region in the gum product.

As used herein, the term “liquid” refers to compositions which willreadily flow or maintain fluid properties at room temperature andpressure. The term “liquid” also includes compositions which may behomogeneous or non-homogeneous mixtures of multiple liquids.

As used herein, the term “ingredient” and the term “component” are usedinterchangeably to describe any additive, fixing, substance, material,agent, active, element, or part that may be included in the gumcompositions of some embodiments.

As used herein, the term “multi-region” refers to compositions with morethan one region with distinct compositions. Such “multi-region”compositions can be configured in any way including concentric multiplelayers, horizontal/vertical layers, and the like. As such, the multiplelayers can surround at least a portion of each and/or can be adjacent toeach other.

As mentioned above, embodiments described herein provide a multi-regionchewing gum composition which includes at least one first region, suchas a center-fill region, and a second region, such as a gum region,which includes an elastomer and a polyol composition, including isomaltalone or in combination with other polyols. The individual gum piecealso may include an outer gum coating or shell, which typically providesa crunchiness to the piece when initially chewed. The individual gumpieces may form a variety of shapes including pellet, tablet, ball,pillow, chunk, stick and slab, among others.

For instance, in some embodiments, the individual gum piece may be inthe form of a slab 10, as shown in FIG. 1. The slab 10 may have a length(l), a width (w) and a thickness (t) being bounded by respective edges12 thereof. The length of the slab may be about 20 mm to about 80 mm,specifically about 25 mm to about 55 mm, and more specifically about 25mm to about 45 mm. The width of the slab may be about 5 mm to about 50mm, specifically about 10 mm to about 30 mm, and more specifically about10 mm to about 15 mm. The thickness of the slab may be about 0.5 mm toabout 30 mm, specifically about 0.5 mm to about 20 mm, and morespecifically about 0.5 mm to about 10 mm. One or more of the edges 12 ofthe slab 10 may have any configuration suitable for a chewing gum piece,such as including a rounded cornet 12 a or a squared corner 12 b, asshown in FIGS. 2 and 3, respectively. As seen in the cross-sectionalview shown in FIG. 4, the slab 10 includes a liquid-fill compositioncenter 100 and a gum region 200 surrounding the liquid-fill compositioncenter.

In some embodiments, an outer coating may at least partially surroundthe slab. In particular, one side of the slab may be coated, two sidesof the slab may be coated, or a coating may surround the entire gumslab. The coating applied to the slab may have a thickness of about 1micron to about 7 mm. Suitable coating compositions are described inmore detail below.

In some embodiments, the components of the composition may be indifferent configurations depending on the desired shape of the total gumcomposition. The first region area or areas may be in either aconcentric configuration with respect to the second region or in alayered configuration. A concentric configuration may be acceptable fora ball, pillow or pellet shape, while a layered configuration may bemore suitable for a slab or a stick shape. For example, if the total gumcomposition is in a ball shape, a hollow, circular shell may be formedin the innermost region of the gum piece. The shell may be filled with afirst region composition, and the other regions or layers of the gumpiece may encircle the center-filled area. However, if the total gumcomposition is in a slab shape, a hollow shell formed in the innermostregion may be of a rectangular shape. The rectangular-shaped shell maybe filled with a first region composition, and the other regions orlayers of the gum piece may enclose or confine the rectangularcenter-filled area on all sides of the rectangle.

In some embodiments, the second region may have a non-uniform thickness.In particular, the second region in layered configuration embodimentsmay be thinner on the ends than on the sides of the gum piece.

The first region of the gain composition may be a liquid, solid orsemi-solid, gas, or the like. Embodiments that include a liquid firstregion composition, as well as some semi-solid first regioncompositions, may involve concerns regarding retention of the liquidcomposition (including both hydrophilic and hydrophobic components)during manufacturing and shelf-life, as mentioned above. It may bedesirable, therefore, to employ second region compositions withliquid-fill gums that substantially reduce or prevent leaking of theliquid composition. Suitable second region compositions are discussed indetail herein.

In some embodiments, the first region may be substantially or completelyfilled with the liquid, solid, semi-solid or gaseous first regioncomposition. In some other embodiments, the first region may be onlypartially filled with the liquid, solid, semi-solid or gaseous firstregion composition.

In some embodiments, the first region may include two or more firstregion compositions. The two or more first region compositions may bethe same or different forms. For example, some embodiments may contain amixture of two or more distinct liquids, which may or may not bemiscible. Similarly, some embodiments may contain two or more distinctsolids, semi-solids or gasses in the first region. Mixtures of differentfirst region forms also may be included in some embodiments. Forexample, a liquid and a solid may be included in the first region. Thetwo or more liquids, solids, semi-solids and/or gasses employed in thefirst region may be included in the same or different amounts and mayhave similar or distinct characteristics. More specifically, in someembodiments, the two or more first region compositions may differ in avariety of characteristics, such as, viscosity, color, flavor, taste,sensation, ingredient components, functional components, sweeteners, orthe like.

In some embodiments, the first region composition also may includenon-liquid components, such as, for example, flavor beads, fruitparticles, nut particles, flavor particles, gelatin portions, and thelike.

The multi-region gum composition and other compositions described hereinmay be formed by any technique known in the art which includes themethod described by U.S. Pat. No. 6,280,780 to Degady et al. (“Degady”)which is herein incorporated by reference in its entirety. Degadydescribes an apparatus and method for forming center-filled gum pellets.The method includes first extruding a liquid-filled rope of a chewinggum layer and passing the rope through a sizing mechanism including aseries of pairs of pulley-shaped roller members. The roller members“size” the rope or strand of gum material such that it leaves the seriesof rollers with the desired size and shape for entering a tablet-formingmechanism.

The rope is then led into a tablet-forming mechanism including a pair ofrotating chain die members which are endless chain mechanisms and bothrotate at the same speed by a motor and gear mechanism. Each of thechain mechanisms include a plurality of open curved die groove memberswhich mate and form die cavities in which the pieces of gum material(pellets or tablets) are formed. While Degady is limited to theformation of pellet or tablet shaped pieces, the gum pieces may be ofother shapes as described above. The shape of the die groove members maybe altered to provide any desired shape.

The gum may optionally be passed through a cooling tunnel either beforeentering the tablet-forming mechanism, after exiting the tablet-formingmechanism or both. Cooling of the rope prior to entering thetablet-forming mechanism may be beneficial to prevent rebound of theindividual pieces and thus may provide an increase in productivity.

The cooled pieces of gum material are then fed into a storage containerfor conditioning and further processing. At this point, the cooledpieces of gum material could also be fed directly into a coating tunnelmechanism, such as a rotating tunnel mechanism.

Whether the pieces of formed gum material are first stored, transportedin a storage container, or fed directly into a coating tunnel ormechanism, the individual pieces of gum material may subsequently besubjected to a conventional sugar or sugarless coating process in orderto form a hard exterior shell on the liquid-filled gum material. Avariety of coating processes or mechanisms of this type are known. Insome embodiments, the coating is applied in numerous thin layers ofmaterial in order to form an appropriate uniform coated and finishedquality surface on the gum products. The hard coating material, whichmay include sugar, maltitol, sorbitol or any other polyol, includingthose described herein, and optionally flavoring, is sprayed onto thepellets of gum material as they pass through a coating mechanism or acoating tunnel and are tumbled and rotated therein. In addition,conditioned air is circulated or forced into the coating tunnel ormechanism in order to dry each of the successive coating layers on theformed products. In some embodiments, the coating, or outermost region,can be formed by lamination, dual or multiple extrusion, or any otherprocess that creates an outermost region.

The coating composition may range from about 2% to about 80%, morespecifically, about 20% to about 40% by weight of an individual gumpiece which includes a first region, a second region and a coating; evenmore specifically, from 25% to 35% and still more specifically around30%. The coating may include sugar or polyol such as maltitol as theprimary component, but may also include flavors, colors. etc. asdescribed below in the discussion of the second region. The coating oroutermost region may be crystalline or amorphous.

In some embodiments, the multi-region chewing gum provides resistance tomigration from the first region to the second region by modifying thesecond region to include isomalt. It may be desirable to prevent or atleast reduce migration of both the hydrophilic, particularly water, andhydrophobic, particularly oil, components contained in the first regioncomposition. This is particularly relevant for liquid-fill chewing gumembodiments. This is in contrast to conventional approaches and whichhave not fully addressed the problems associated with manufacturing andshelf-stability of liquid center-filled products.

The size of the multi-region chewing gum product may also affect theperformance and stability of the gum composition. For instance, forcenter-fill pellets, the gum size is optimally between about 18-21 mm inlength, about 12-16 mm in width, and about 7-10 mm in height. Desirably,the gum piece is about 19 mm in length, about 14 mm in width, and about8 mm in height. The gum piece (with coating) optimally weighs about1.5-3 grams, and most desirably about 2 grams.

In some embodiments, there are included smaller piece-sizes.Historically, liquid center-filled gum piece sizes ranged from about 5-7grams. In some embodiments described herein, liquid filled products havebeen made using substantially smaller piece sizes, i.e., 50-60% smallerby weight, without loss of liquidity or migration of liquid into the gumregion or beyond into the coating. Some embodiments provide aliquid-filled gum piece size range which is greater than about 0.5grams, more specifically greater than 1.5 grams up to about 3 grams,including the addition of an outer hard coating shell. In addition, insome embodiments a gum piece may include a first region, such as acenter-fill, a second region, such as a gum region including anelastomer, and an outer coating. Such gum pieces may be about 2.2 gramstotal weight per piece.

With respect to liquid-fill embodiments, it has been discovered thatpieces of such small size and particularly with gum shapes orconfigurations having proportionally more liquid-fill surface area ascompared to the weight of the liquid per se, have a greater tendency tolose the liquidity of the first region due to the interaction ofdifferent factors. While not limited to a single theory, these factorsinclude the small amount of liquid-fill in comparison to the surface ofthe second, or gum, region in which the liquid-fill is in directcontact, the interaction of the type of elastomer with the liquid-fill(i.e. SBR versus non-SBR), the compatibility of the second regioncomponents with the liquid-fill components, and the potential capillaryaction of the polyol used in the second region. For example, thestructure of sorbitol, which is customarily used in gum formulations inthe United States, does not provide a tightly packed crystallinestructure, giving almost a sponge-like appearance. Therefore, in orderto provide a multi-region gum piece of less than about 3 grams, thepresent invention alters the second region to include a polyolcomposition which is unlike the sponge-like structure in conventionalsorbitol second region formulations, in order to provide a multi-regiongum piece which resists loss of liquidity.

For other useful multi-region gum compositions and/or components for usetherein, see the following co-pending commonly owned patentapplications, the contents of which are incorporated herein by referencein their entirety: U.S. application Ser. No. 11/710,830 (Attorney DocketNo. 1421-5 CIP II), filed on Feb. 26, 2007, entitled “Liquid-FilledChewing Gum Composition”; U.S. application Ser. No. 11/710,758 (AttorneyDocket No. 1421-5 CIP III), filed on Feb. 26, 2.007, entitled“Liquid-Filled Chewing Gum Composition”; U.S. application Ser. No.11/408,761 (Attorney Docket No. 1421-5 CIP IV), filed on Apr. 21, 2006,entitled “Liquid-Filled Chewing Gum Composition”; U.S. application Ser.No. 11/411,543 (Attorney Docket No. 1421-137), filed on Apr. 26, 2006,entitled “Center-Filled Chewing Gum with Barrier Layer”; U.S.application Ser. No. 11/414,919 (Attorney Docket No. 1421-138A), filedon May 1, 2006, entitled “Center-Filled Chewing Gum Composition”; andU.S. application Ser. No. 11/415,043 (Attorney Docket No. 1421-139A),filed on May 1, 2006, entitled “Multi-Modality Chewing Gum Composition”.

Second or Gum Region

The gum region, also referred to as the second region in the claims, mayinclude one or more cavities therein to house the first regioncomposition. The shape of the cavity will be largely dictated by thefinal configuration of the chewing gum piece. The second region also mayinclude a polyol composition including isomalt alone or in combinationwith at least a second polyol, such as sorbitol.

In some liquid-fill embodiments, the second region may provide a liquidbarrier to surround and prevent the liquid-fill from migration andpremature release. By selection of the ratio of the desired cavitysurface area to the liquid-fill weight, optimization of the reduction inpotential liquid-fill migration in to the gum region area can beachieved. This is particularly useful when the gum piece size is desiredto be substantially smaller than conventional commercialized gum pieces.In particular, liquid-filled pellet gums having sizes of 2 to 3 grams byweight of the entire gum piece have been successfully made. However,smaller gum pieces, as small as about 0.5 grams are contemplated.

As mentioned above, the second region includes an elastomer and a polyolcomposition. In some embodiments, the second, or gum, region includes agum base and a polyol composition. The polyol composition includesisomalt alone or in combination with one or more additional polyols,such as sorbitol, maltitol, erythritol, xylitol, mannitol, lactitol, orthe like, and combinations thereof. The isomalt-based gum regionimproves the stability and machinability of multi-region chewing gumpieces made from the chewing gum compositions described herein.

The gum base may include any component known in the chewing gum art. Forexample, the second region may include elastomers, bulking agents,waxes, elastomer solvents, emulsifiers, plasticizers, fillers andmixtures thereof. Wherein the second region is included in a threecomponent composition including a first region, a second region and acoating layer, the second region may comprise from about 40% to about97%, more specifically from about 55% to about 65% by weight of thechewing gum piece, even more specifically about 62%.

The amount of the gum base, such as the elastomer(s), which is presentin the gum region may also vary. In some embodiments, the gum base maybe included in the gum region in an amount from about 25% to about 45%by weight of the gum regions. A more specific range of gum base in someembodiments may be from about 28% to about 42% by weight of the gumregion. Even more specifically, the range may be from about 28% to about35% or from about 28% to about 30% in some embodiments. Alternatively,in some high gum base embodiments, the gum base may be present in anamount from about 45% to about 100% by weight of the gum region.

The elastomers (rubbers) employed in the gum base will vary greatlydepending upon various factors such as the type of gum base desired, theconsistency of gum composition desired and the other components used inthe composition to make the final chewing gum product. The elastomer maybe any water-insoluble polymer known in the art, and includes those gumpolymers utilized for chewing gums and bubble gums. Illustrativeexamples of suitable polymers in gum bases include both natural andsynthetic elastomers. For example, those polymers which are suitable ingum base compositions include, without limitation, natural substances(of vegetable origin) such as chicle, natural rubber, crown gum,nispero, rosidinha, jelutong, perillo, niger gutta, tunu, balata,guttapercha, lechi capsi, sorva, gutta kay, and the like, andcombinations thereof. Examples of synthetic elastomers include, withoutlimitation, styrene-butadiene copolymers (SBR), polyisobutylene,isobutylene-isoprene copolymers, polyethylene, polyvinyl acetate and thelike, and combinations thereof. Copolymers include alternatingcopolymers with regular alternating A and B units, periodic copolymerswith A and B units arranged in a repeating sequence (e.g.(A-B-A-B-B-A-A-A-A-B-B-B)_(n) random copolymers with random sequences ofmonomer A and B, statistical copolymers in which the ordering of thedistinct monomers within the polymer sequence obeys known statisticalrules, and block copolymers.

Additional useful polymers include: crosslinked polyvinyl pyrrolidone,polymethylmethacrylate; copolymers of lactic acid,polyhydroxyalkanoates, plasticized ethylcellulose, polyvinylacetatephthalate and combinations thereof.

The amount of elastomer employed in the gum base may vary depending uponvarious factors such as the type of gum base used, the consistency ofthe gum composition desired and the other components used in thecomposition to make the final chewing gum product. In general, theelastomer will be present in the gum base in an amount from about 10% toabout 60% by weight of the gum region, desirably from about 35% to about40% by weight.

In some embodiments, the gum base may include wax. It softens thepolymeric elastomer mixture and improves the elasticity of the gum base.When present, the waxes employed will have a melting point below about60° C., and preferably between about 45° C. and about 55° C. The lowmelting wax may be a paraffin wax. The wax may be present in the gumbase in an amount from about 6% to about 10%, and preferably from about7% to about 9.5%, by weight of the gum base.

In addition to the low melting point waxes, waxes having a highermelting point may be used in the gum base in amounts up to about 5%, byweight of the gum base. Such high melting waxes include beeswax,vegetable wax, candelilla wax, carnuba wax, most petroleum waxes, andthe like, and mixtures thereof.

In addition to the components set out above, the gum base may include avariety of other ingredients, such as components selected from elastomersolvents, emulsifiers, plasticizers, fillers, and mixtures thereof.

The gum base may contain elastomer solvents to aid in softening theelastomer component. Such elastomer solvents may include those elastomersolvents known in the art, for example, terpinene resins such aspolymers of alpha-pinene or beta-pinene, methyl, glycerol andpentaerythritol esters of rosins and modified rosins and gums such ashydrogenated, dimerized and polymerized rosins, and mixtures thereof.Examples of elastomer solvents suitable for use herein may include thepentaerythritol ester of partially hydrogenated wood and gum rosin, thepentaerythritol ester of wood and gum rosin, the glycerol ester of woodrosin, the glycerol ester of partially dimerized wood and gum rosin, theglycerol ester of polymerized wood and gum rosin, the glycerol ester oftall oil rosin, the glycerol ester of wood and gum rosin and thepartially hydrogenated wood and gum rosin and the partially hydrogenatedmethyl ester of wood and rosin, and the like, and mixtures thereof. Theelastomer solvent may be employed in the gum base in amounts from about2% to about 15%, and preferably from about 7% to about 11%, by weight ofthe gum base.

The gum base may also include emulsifiers which aid in dispersing theimmiscible components into a single stable system. The emulsifiersuseful in this invention include glyceryl monostearate, lecithin, fattyacid monoglycerides, diglycerides, propylene glycol monostearate, andthe like, and mixtures thereof. The emulsifier may be employed inamounts from about 2% to about 15%, and more specifically, from about 7%to about 11%, by weight of the gum base.

The gum base may also include plasticizers or softeners to provide avariety of desirable textures and consistency properties. Because of thelow molecular weight of these ingredients, the plasticizers andsofteners are able to penetrate the fundamental stricture of the gumbase making it plastic and less viscous. Useful plasticizers andsofteners include lanolin, palmitic acid, oleic acid, stearic acid,sodium stearate, potassium stearate, glyceryl triacetate, glyceryllecithin, glyceryl monostearate, propylene glycol monostearate,acetylated monoglyceride, glycerine, and the like, and mixtures thereof.Waxes, for example, natural and synthetic waxes, hydrogenated vegetableoils, petroleum waxes such as polyurethane waxes, polyethylene waxes,paraffin waxes, microcrystalline waxes, fatty waxes, sorbitanmonostearate, tallow, propylene glycol, mixtures thereof, and the like,may also be incorporated into the gum base. The plasticizers andsofteners are generally employed in the gum base in amounts up to about20% by weight of the gum base, and more specifically in amounts fromabout 9% to about 17%, by weight of the gum base.

Plasticizers also include are the hydrogenated vegetable oils andinclude soybean oil and cottonseed oil which may be employed alone or incombination. These plasticizers provide the gum base with good textureand soft chew characteristics. These plasticizers and softeners aregenerally employed in amounts from about 5% to about 14%, and morespecifically in amounts from about 5% to about 13.5%, by weight of thegum base.

Anhydrous glycerin may also be employed as a softening agent, such asthe commercially available United States Pharmacopeia (USP) grade.Glycerin is a syrupy liquid with a sweet warm taste and has a sweetnessof about 60% of that of cane sugar. Because glycerin is hygroscopic, theanhydrous glycerin may be maintained under anhydrous conditionsthroughout the preparation of the chewing gum composition.

In some embodiments, the gum base may also include effective amounts ofbulking agents such as mineral adjuvants which may serve as fillers andtextural agents. Useful mineral adjuvants include calcium carbonate,magnesium carbonate, alumina, aluminum hydroxide, aluminum silicate,talc, tricalcium phosphate, dicalcium phosphate, calcium sulfate and thelike, and mixtures thereof. These fillers or adjuvants may be used inthe gum base compositions in various amounts. The amount of filler, maybe present in an amount from about zero to about 40%, and morespecifically from about zero to about 30%, by weight of the gum base. Insome embodiments, the amount of filler will be from about zero to about15%, more specifically from about 3% to about 11%.

A variety of traditional ingredients may be optionally included in thegum base in effective amounts such as coloring agents, antioxidants,preservatives, flavoring agents, high intensity sweeteners, and thelike. For example, titanium dioxide and other dyes suitable for food,drug and cosmetic applications, known as F. D. & C. dyes, may beutilized. An anti-oxidant such as butylated hydroxytoluene (BHT),butylated hydroxyanisole (BHA), propyl gallate, and mixtures thereof,may also be included. Other conventional chewing gum additives known toone having ordinary skill in the chewing gum art may also be used in thegum base. A variety of components which may be added to the gum region,or alternatively to the liquid-fill region or coating are described ingreater detail in the section entitled “Additional Components”hereinbelow.

Some embodiments extend to methods of making the multi-region gumcompositions. The manner in which the gum base components are mixed isnot critical and is performed using standard techniques and apparatusknown to those skilled in the art. In a typical method, an elastomer isadmixed with an elastomer solvent and/or a plasticizer and/or anemulsifier and agitated for a period of from 1 to 30 minutes. Theremaining ingredients, such as the low melting point wax, are thenadmixed, either in bulk or incrementally, while the gum base mixture isblended again for 1 to 30 minutes.

The gum composition may include amounts of conventional additivesselected from the group consisting of sweetening agents (sweeteners),plasticizers, softeners, emulsifiers, waxes, fillers, bulking agents(carriers, extenders, bulk sweeteners), mineral adjuvants, flavoringagents (flavors, flavorings), coloring agents (colorants, colorings),antioxidants, acidulants, thickeners, medicaments, and the like, andmixtures thereof. Some of these additives may serve more than onepurpose. For example, in sugarless gum compositions, a sweetener, suchas maltitol or other sugar alcohol, may also function as a bulkingagent.

The plasticizers, softening agents, mineral adjuvants, waxes andantioxidants discussed above, as being suitable for use in the gum base,may also be used in the chewing gum composition. Examples of otherconventional additives which may be used include emulsifiers, such aslecithin and glyceryl monostearate, thickeners, used alone or incombination with other softeners, such as methyl cellulose, alginates,carrageenan, xanthan gum gelatin, carob, tragacanth, locust bean gum,pectin, alginates, galactomannans such as guar gum, carob bean gum,glucomannan, gelatin, starch, starch derivatives, dextrins and cellulosederivatives such as carboxy methyl cellulose, acidulants such as malicacid, adipic acid, citric acid, tartaric acid, fumaric acid, andmixtures thereof, and fillers, such as those discussed above under thecategory of mineral adjuvants.

In some embodiments, the second region may also contain a bulking agent.Suitable bulking agents may be water-soluble and include sweeteningagents selected from, but not limited to, monosaccharides,disaccharides, polysaccharides, sugar alcohols, and mixtures thereof;randomly bonded glucose polymers such as those polymers distributedunder the tradename Litesse™ which is the brand name for polydextroseand is manufactured by Danisco Sweeteners, Ltd. of 41-51 Brighton Road,Redhill, Surryey, RH1 6YS, United Kingdom.; isomalt (a racemic mixtureof alpha-D-glucopyranosyl-1,6-mannitol andalpha-D-glucopyranosyl-1,6-sorbitol manufactured under the tradenamePALATINIT by Palatinit Sussungsmittel GmbH of Gotlieb-Daimler-Strause 12a, 68165 Mannheim, Germany); maltodextrins; hydrogenated starchhydrolysates; hydrogenated hexoses; hydrogenated disaccharides;minerals, such as calcium carbonate, talc, titanium dioxide, dicalciumphosphate; celluloses; and mixtures thereof.

Suitable sugar bulking agents include monosaccharides, disaccharides andpolysaccharides such as xylose, ribulose, glucose (dextrose), lactose,mannose, galactose, fructose (levulose), sucrose (sugar), maltose,invert sugar, partially hydrolyzed starch and corn syrup solids, andmixtures thereof.

Suitable sugar alcohol bulking agents include sorbitol, xylitol,mannitol, galactitol, lactitol, maltitol, erythritol, isomalt andmixtures thereof.

Suitable hydrogenated starch hydrolysates include those disclosed inU.S. Pat. No. 4,279,931 and various hydrogenated glucose syrups and/orpowders which contain sorbitol, maltitol, hydrogenated disaccharides,hydrogenated higher polysaccharides, or mixtures thereof. Hydrogenatedstarch hydrolysates are primarily prepared by the controlled catalytichydrogenation of corn syrups. The resulting hydrogenated starchhydrolysates are mixtures of monomeric, dimeric, and polymericsaccharides. The ratios of these different saccharides give differenthydrogenated starch hydrolysates different properties. Mixtures ofhydrogenated starch hydrolysates, such as LYCASIN®, a commerciallyavailable product manufactured by Roquette Freres of France, andHYSTAR®, a commercially available product manufactured by SPI Polyols,Inc. of New Castle, Del., are also useful.

The sweetening agents which may be included in the compositions of someembodiments may be any of a variety of sweeteners known in the art.These are described in more detail in the “Additional Components”section herein below and may be used in many distinct physical formswell-known in the art to provide an initial burst of sweetness and/or aprolonged sensation of sweetness. Without being limited thereto, suchphysical forms include free forms, such as spray dried, powdered, beadedforms, encapsulated forms, and mixtures thereof.

Desirably, the sweetener is a high intensity sweetener such asaspartame, neotame, sucralose, and acesulfame potassium (Ace-K).

In general, an effective amount of sweetener may be utilized to providethe level of sweetness desired, and this amount may vary with thesweetener selected. In some embodiments the amount of sweetener may bepresent in amounts from about 0.001% to about 3%, by weight of the gumcomposition, depending upon the sweetener or combination of sweetenersused. The exact range of amounts for each type of sweetener may beselected by those skilled in the art.

In some embodiments, particularly liquid-fill embodiments, the secondregion may include a specific polyol composition including at least onepolyol which is from about 30% to about 80% by weight of said secondregion, and specifically from 50% to about 60%. In some liquid-fillembodiments, such second region compositions may substantially reduce orprevent leaking of the liquid first region composition. The polyolcomposition may include any polyol known in the art including, but notlimited to maltitol, sorbitol, erythritol, xylitol, mannitol, isomalt,lactitol and combinations thereof. Lycasin™ which is a hydrogenatedstarch hydrolysate including sorbitol and maltitol, may also be used.

Since sugar (sucrose) is generally accepted as the baseline forcomparison of sweeteners, including polyols, the polyol composition ofsome embodiments is described similarly. For example, the polyolcomposition of may have a sweetness of greater than about 50% of thesweetness of sucrose. More specifically, in some embodiments, the polyolcomposition of the present invention may have sweetness greater thanabout 70% the sweetness of sucrose.

The polyol composition of some embodiments may also be described interms of the solubility of the composition. The solubility of the polyolcomposition will depend on the solubility of the one or more polyolsincluded in the composition.

Blends of different polyols may also be used in some embodiments.Examples of useful polyols are erythritol, lactitol, xylitol, mannitol,maltitol, sorbitol, isomalt, and combinations thereof. Where a blend ofmore than one polyol is used, the solubility of the polyol compositionwill depend on a weighted ratio of the amount of the polyol in the blendand the solubility of each individual polyol which is included. Forexample, in some embodiments, a combination of two or more polyols mayhave a water solubility range of about 60% to about 72%, if t includesmaltitol, which has a water solubility of 60% at 25° C., and sorbitol,which has a water solubility of about 72% at 25° C. Other suitablesolubility ranges, which depend on the included two or more polyolsinclude the ranges from about 40% to about 60% at 25° C. and 55% to 65%at 25° C. The range of the solubility may vary, depending on theparticular polyols used. Alternative suitable solubilities of a polyolcombination include those having a solubility less than sucrose (i.e.,less than 67%).

Coloring agents may be used in amounts effective to produce the desiredcolor. The coloring agents may include pigments which may beincorporated in amounts up to about 6%, by weight of the gumcomposition. For example, titanium dioxide may be incorporated inamounts up to about 2%, and preferably less than about 1%, by weight ofthe gum composition. The colorants may also include natural food colorsand dyes suitable for food, drug and cosmetic applications. Thesecolorants are known as F.D.& C. dyes and lakes. The materials acceptablefor the foregoing uses are preferably water-soluble. Illustrativenonlimiting examples include the indigoid dye known as F.D.& C. Blue No.2, which is the disodium salt of 5,5-indigotindisulfonic acid.Similarly, the dye known as F.D.& C. Green No. 1 comprises atriphenylmethane dye and is the monosodium salt of4-[4-(N-ethyl-p-sulfoniumbenzylamino)diphenylmethylene]-[1-(N-ethyl-N-p-sulfoniumbenzyl)-delta-2,5-cyclohexadieneimine].A full recitation of all F.D.& C. colorants and their correspondingchemical structures may be found in the Kirk-Othmer Encyclopedia ofChemical Technology, 3rd Edition, in volume 5 at pages 857-884, whichtext is incorporated herein by reference. Additional coloring componentsare described in the “Additional Components” section hereinbelow.

Suitable oils and fats usable in gum compositions include partiallyhydrogenated vegetable or animal fats, such as coconut oil, palm kerneloil, beef tallow, and lard, among others. These ingredients when usedare generally present in amounts up to about 7%, and preferably up toabout 3.5%, by weight of the gum composition.

Some embodiments may include a method for preparing the improved chewinggum compositions for the second region, including both chewing gum andbubble gum compositions. The chewing gum compositions may be preparedusing standard techniques and equipment known to those skilled in theart. The apparatus useful in accordance with some embodiments comprisesmixing and heating apparatus well known in the chewing gum manufacturingarts, and therefore the selection of the specific apparatus will beapparent to the artisan.

With respect to the first region composition, the second region may havea water activity greater than or equal to the water activity of thefirst region composition. However, in compositions wherein a greaterwater activity is desired in the first region, the water activity of thefirst region composition may be greater than that of the second region.A higher moisture content will aid in hydration of thickeners likexanthan gum and cellulose when present in the first region composition.

In some embodiments, the second region may have a total moisture contentof about 14% by weight of the second region and more specifically mayhave a total moisture content from about 9% to about 14% by weight, witha free moisture content of less than about 5%. The first region furthermay have total moisture content including free and bound moisture fromabout zero up to about 35% by weight of said first region, specificallyabout 22%, in some embodiments.

First Region or Center-Fill Composition

The center-fill, also referred to as the first region or interiorportion, of the chewing gum composition can take the physical form of asolid, a liquid, a semi-solid or a gas. Depending on the physical formof the first region composition, adjustments can be made to the adjacentportion of the chewing gum composition that will be in contact with thefirst region.

In some embodiments, liquid first region compositions may presentviscosity differences that can be manipulated for a desired effect. Insome embodiments, liquid first region compositions can be formulated tohave low viscosities that consumers perceive as refreshing.

In some embodiments, solid first region compositions may be particulateor unitary. In embodiments where the solid first region composition isparticulate, the first region composition can include a plurality ofparticles. In some particulate solid first region compositionembodiments, variables such as particle size and particle sizedistribution can be manipulated for a desired effect. In someembodiments, small particles with narrow particle size distribution canbe included in the first region composition to provide rapid dissolutionwhen contacted with saliva.

In embodiments where the solid first region composition is unitary, thefirst region composition can include a cohesive mass where distinctparticles are not discernible. In some unitary solid first regioncomposition embodiments, the texture can be manipulated for a desiredeffect. In some embodiments, a unitary solid first region compositioncan include a confectionery format such as nougat to provide a chewytexture experience.

In some embodiments, gaseous first region compositions can form a voidin the chewing gum composition that alters the chewing gum composition'stexture profile by collapsing upon chewing. In some embodiments, thegaseous first region composition can include a trapped gas such asnitrogen while in other embodiments, the gaseous first regioncomposition can include a mixed gas composition such as air. In someembodiments, the gas can be included in the first region composition aspart of a matrix such as a foam or glassy matrix.

Additionally in some embodiments, the physical form of the first regioncomposition can change. In some embodiments, the first regioncomposition can be solid when manufactured and then become liquid overtime. In some embodiments, the initially solid first region compositioncan be a substrate-enzyme blend where the enzyme acts upon the substrateto liquefy the solid. In other embodiments, the initial solid firstregion composition can be a solid at a manufacturing temperature that islower than the storage temperature such that the first regioncomposition liquefies as the temperature reaches the storagetemperature. In some embodiments, the first region composition is aliquid-filled particle that remains solid until ruptured or disruptedwhen it releases liquid. In some embodiments, the initially solid firstregion composition can interact with an adjacent region configured tocontain free moisture such that the first region composition pullsmoisture from the adjacent region and becomes liquid.

Solid First Region Compositions

In some embodiments, the solid first region composition can includeparticulates. Particulates can include, but are not limited to nuts;seeds; cocoa beans; coffee beans; milk powders; fruit-containingparticles such as restructured fruit as described in U.S. Pat. No.6,027,758; freeze dried fruit; freeze dried vegetables; fat particles;cocoa powder; sucrose; starch; polyols such as xylitol, erythritol,sorbitol, mannitol, maltitol, isomalt, hydrogenated starch hydrolysates;waxes; and combinations thereof.

In some embodiments, the solid first region composition can includeparticles onto which other materials have been complexed. In someembodiments, the solid particle can include an absorbent material towhich a second material is absorbed. In some embodiments, the solidparticle can include an adsorbent material to which a second material isadsorbed. In some embodiments, the solid particle can include acomplexation material to which a second material is complexed. In someembodiments, silica particles can absorb at least a second material toform a particulate solid interior portion. In some embodiments,cyclodextrin particles can complex with at least a second material toform a particulate solid interior portion.

In some embodiments where the solid first region composition can changeto a liquid, the solid first region composition can include a mixture ofinvertase and sucrose such invertase operates on sucrose to form liquidinvert sugar resulting in a liquid first region composition over time.In some embodiments, the first region composition can be a fat withmelting characteristics such that at manufacturing temperatures the fatis solid and then melts to become liquid at storage temperatures. Insome embodiments, the solid first region composition can includeliquid-filled gelatin or sucrose beads that release liquid when rupturedor disrupted.

In some embodiments, the solid first region composition can include aunitary or particulate solid confectionery composition. Suchconfectionery compositions can include, but are not limited to,chocolate, compound coating, carob coating, cocoa butter, butter fat,hydrogenated vegetable fat, illipe butter, fondant includingfondant-based cremes, fudge, frappe, caramel, nougat, compressed tablet,candy floss (also known as cotton candy), marzipan, hard boiled candy,gummy candy, jelly beans, toffees, jellies including pectin-based gels,jams, preserves, butterscotch, nut brittles or croquant, candied fruit,marshmallow, pastilles, pralines or nougats, flour or starchconfectionery, truffles, nonpareils, bon bons, after-dinner mints,fourres, nut pastes, peanut butter, chewing gum, kisses, angel kisses,montelimart, nougatine, fruit chews, Turkish delight, hard gums, softgums, starch jellies, gelatin jellies, agar Jellies, persipan, coconutpaste, coconut ice, lozenges, cachous, crème paste, dragees, sugarednuts, sugared almonds, comfits, aniseed balls, licorice, licorice paste,chocolate spreads, chocolate crumb, and combinations thereof.

Liquid First Region Compositions

In some embodiments, the liquid first region composition can be aqueouswhile in other embodiments the liquid first region composition can benon-aqueous. In some embodiments, the liquid first region compositioncan be a solution while in other embodiments, the first regioncomposition can be a suspension while in still other embodiments, thefirst region composition can be an emulsion.

In some embodiments, the viscosity of the liquid first regioncomposition can be manipulated for a variety of reasons including, butnot limited to, processing efficiency or creation of a desiredperception. In some embodiments, the viscosity of the liquid firstregion composition can be 3,000 to 10,000 pascal seconds. In someembodiments, the viscosity of the liquid first region composition can be4,000 to 6,5000 pascal seconds.

In some embodiments, the water activity of the liquid first regioncomposition can be manipulated for a variety of reasons including, butnot limited to microbial stability or maintenance of a desired texture.In some embodiments, the water activity of the liquid first regioncomposition can be 0.1 to 0.7. In some embodiments, the water activityof the liquid first region composition can be 0.25 to 0.35.

Liquids that can be included in the liquid first region composition caninclude, but are not limited to, fruit juice; vegetable juice; fruitpuree; fruit pulp; vegetable pulp; vegetable puree; fruit sauce;vegetable sauce; honey; maple syrup; molasses; corn syrup; sugar syrup;polyol syrup; hydrogenated starch hydrolysates syrup; emulsions;vegetable oil; glycerin; propylene glycol; ethanol; liqueurs; chocolatesyrup, dairy-based liquids such as milk, cream, etc.; and combinationsthereof.

Gaseous First Region Compositions

In some embodiments, a gaseous first region composition can be formed bycreating a hollow center. The gas can include a mixed composition gassuch as air or it can include a single gas such as nitrogen, carbondioxide, or oxygen. In some embodiments, a gaseous first regioncomposition will include gas trapped in a matrix such as a glassy matrixor foam. In some embodiments where gas can be trapped in a glassymatrix, the glass can be sucrose and the gas can be carbon dioxide. Insome embodiments where gas can be introduced into the first regioncomposition in a foam, the foam can include milk proteins and the gascan include a mixed composition gas such as air.

Any of the first region compositions discussed above may include anycomponents known in the art for incorporation with a center-tillcomposition. In some embodiments, particularly liquid-fill embodiments,for instance, this may include glycerine in addition to one or moreother polyols in amounts greater than zero up to about 20%, morespecifically, up to about 10% by weight of the total chewing gumcomposition, i.e., including a first region composition, a second regionand a coating. In some embodiments, the first region is approximately 8%by weight of the total chewing gum composition. In some embodiments, theother polyol component includes desirably maltitol, sorbitol, xylitol,or a combination thereof.

In some embodiments, the first region compositions may contain thosetraditional ingredients well known in the chewing gum and confectioneryarts, such as flavoring agents, sweetening agents, and the like, andmixtures thereof, as described above. In addition to confectioneryadditives, the first region compositions may also contain pharmaceuticaladditives such as medicaments, breath fresheners, vitamins, minerals,caffeine, fruit juices, and the like, and mixtures thereof. Theconfectionery and pharmaceutical agents may be used in many distinctphysical forms well known in the art to provide an initial burst ofsweetness and flavor and/or therapeutic activity or a prolongedsensation of sweetness and flavor and/or therapeutic activity. Withoutbeing limited thereto, such physical forms include free forms, such asspray dried, powdered, and beaded forms, and encapsulated forms, andmixtures thereof. Illustrative, but not limiting, examples of liquidcenters suitable for use in some embodiments include those centersdisclosed in U.S. Pat. Nos. 3,894,154, 4,156,740, 4,157,402, 4,316,915,and 4,466,983, which disclosures are incorporated herein by reference.Specific examples of suitable additional components include taurine,guarana, vitamins, Actizol™, chlorophyll, Recaldent™ toothremineralization technology, and Retsyn™ .breath freshening technology.

In some embodiments, particularly liquid-fill embodiments, the firstregion composition also may include a natural or synthetic gum such ascarboxymethylcellulose, pectin, propylene glycol aginate, agar and gumtragacanth. These compositions serve to increase viscosity by reducingthe amount of free water in the composition. The viscosity of the firstregion composition may range from about 300 cp to about 6,000 cp at 25°C. In first region compositions which have a greater water activity thanthe surrounding second region, the viscosity may range from about 3,000cp to about 6,000 cp at 25° C.

Xanthan gum may also be used to increase the viscosity of the firstregion composition. In some liquid-fill embodiments, increasingviscosity of the liquid also helps prevent the liquid from leakingthrough the gum piece. Xanthan gum is available under the tradenameKeltrol® from Signet Chemical Corporation.

Some embodiments extend to methods of making, the improved multi-regionchewing gum compositions. The improved compositions may be preparedusing standard techniques and equipment known to those skilled in theart. The apparatus useful in accordance with the embodiments describedherein comprises mixing and heating apparatus well known in the chewinggum manufacturing arts, and therefore the selection of the specificapparatus will be apparent to the artisan. Such methods and apparatusare disclosed, for example, in U.S. Pat. Nos. 3,806,290 and 857,963,which disclosures are incorporated herein by reference.

Coating Composition

The coating composition, when included in the multi-region chewing gumcompositions, may be applied by any method known in the art includingthe method described above. The coating composition may be present in anamount from about 2% to about 60%, more specifically from about 25% toabout 35% by weight of the total multi-region gum piece, even morespecifically about 30% by weight of the gum piece.

The outer coating may be hard, crunchy, or soft. Typically, the outercoating may include sorbitol, maltitol, xylitol, erythritol, isomalt,and other crystallizable polyols; sucrose may also be used. Furthermorethe coating may include several opaque layers, such that the chewing gumcomposition is not visible through the coating itself, which canoptionally be covered with a further one or more transparent layers foraesthetic, textural and protective purposes. The outer coating may alsocontain small amounts of water and gum arabic. The coating can befurther coated with wax. The coating may be applied in a conventionalmanner by successive applications of a coating solution, with drying inbetween each coat. As the coating dries it usually becomes opaque and isusually white, though other colorants may be added. A polyol coating canbe further coated with wax. The coating can further include coloredflakes or speckles. If the composition comprises a coating, it ispossible that one or more oral care actives can be dispersed throughoutthe coating. This is especially preferred if one or more oral careactives is incompatible in a single phase composition with another ofthe actives. Flavors may also be added to yield unique productcharacteristics.

In some embodiments, the coating may also be formulated to assist withincreasing the thermal stability of the gum piece and preventing leakingof the liquid fill. In some embodiments, the coating may include agelatin composition. The gelatin composition may be added as a 40% byweight solution and may be present in the coating composition from about5% to about 10% by weight of the coating composition, and morespecifically about 7% to about 8%. The gel strength of the gelatin maybe from about 130 bloom to about 250 bloom.

Other materials may be added to the coating to achieve desiredproperties. These materials may include without limitation, cellulosicssuch as carboxymethyl cellulose, gelatin, pullulan, alginate, starch,carrageenan, xanthan gum, gum arabic and polyvinyl acetate (PVA).

The coating composition may also include a pre-coating which is added tothe individual gum pieces prior to an optional hard coating. Thepre-coating may include an application of polyvinyl acetate (PVA). Thismay be applied as a solution of PVA in a solvent, such as ethyl alcohol.When an outer hard coating is desired, the PVA application may beapproximately 3% to 4% by weight of the total coating or about 1% of thetotal weight of the gum piece (including a first region composition,second region and hard coating).

Various other coating compositions and methods of making are alsocontemplated including but not limited to soft panning, dual or multipleextrusion, lamination, etc. Thus, in some embodiments, the coating canbe amorphous or crystalline and the resulting texture can be hard,crunchy, crispy, soft, or chewy.

Additional Components

Additional additives, such as warming agents, cooling agents, tinglingagents, flavors, sweeteners, sour tastes, bitter tastes, salty tastes,surfactants, breath freshening agents, anti-microbial agents,anti-bacterial agents, anti-calculus agents, antiplaque agents, fluoridecompounds, remineralization agents, pharmaceuticals, micronutrients,throat care actives, tooth whitening agents, energy boosting agents,concentration boosting agents, appetite suppressants, colors and otheractives may also be included in any or all portions or regions of thechewing gum composition. Such components may be used in amountssufficient to achieve their intended effects.

Any of the additional components discussed herein may be added to anyregion of the multi-region chewing gum composition in their modifiedrelease form and/or without modified release (sometimes referred to as“free” components). In some embodiments, for instance, a singlecomponent may be added to the first region composition in its modifiedrelease form and free form. The modified release component and freecomponent may be included together in the same region of themulti-region composition or, in some embodiments, the two components maybe included in different regions of the composition.

In some other embodiments, for instance, two different components thatprovide the same functionality, e.g., two different flavors, sweeteners,tastes, sensations, or the like, may be included in a multi-regionchewing gum composition. In some embodiments, both components may havemodified release properties. Alternatively, in some embodiments, one ofthe components may be modified release, whereas the other component maybe free. The two components may be included in the same or differentregions of the multi-region composition.

Types of individual ingredients for which optional managed release froma chewing gun composition may be desired, include, but are not limitedto sweeteners, flavors, actives, effervescing ingredients, appetitesuppressors, breath fresheners, dental care ingredients, emulsifiers,flavor potentiators, bitterness masking or blocking ingredients, foodacids, micronutrients, sensates, mouth moistening ingredients, throatcare ingredients, colors, sour agents, bitter agents, salty agents,pharmaceuticals, energy boosting agents, concentration boosting agentsand combinations thereof. Ingredients may be available in differentforms such as, for example, liquid form, spray-dried form, orcrystalline form. In some embodiments, chewing gum composition mayinclude the same type of ingredient in different forms. For example, achewing gum composition may include a liquid flavor and a spray-driedversion of the same flavor. In some embodiments, the ingredient may bein its free or encapsulated form and may be present in any region of thegum composition such as in the first region composition, the secondregion, or the coating.

In some embodiments, an ingredient's release is modified such that whena consumer chews the chewing gum, they may experience an increase in theduration of flavor or sweetness perception and/or the ingredient isreleased or otherwise made available over a longer period of time.Modified release may be accomplished by any method known in the art,such as by encapsulation. Where modified release is due toencapsulation, this may be accomplished by a variety of means such as byspray coating or extrusion.

Additionally, if early and extended release of the ingredient isdesired, the chewing gum composition may include ingredients withoutmodified release (sometimes referred to as “free” ingredients), as wellas ingredients with modified release. In some embodiments, a freeingredient may be used to deliver an initial amount or “hit” of aningredient (e.g., Flavor, cooling agent) or an initial sensation orbenefit caused by the ingredient (e.g., flavor, nasal action, cooling,warming, tingling, saliva generation, breath freshening, teethwhitening, throat soothing, mouth moistening, etc.). In someembodiments, the same ingredient can be provided with modified releasecharacteristics to provide an additional or delayed amount of the samesensation or benefit. By using both the free ingredient and theingredient with modified release characteristics, the sensation orbenefit due to the ingredient may be provided over a longer period oftime and/or perception of the sensation or benefit by a consumer may beimproved. Also, in some embodiments the initial amount or “hit” of theingredient may predispose or precondition the consumers' mouth orperception of the chewing gum composition.

As another example, in some embodiments it may be desirable to provide asustained release of an ingredient in a chewing gum composition overtime. To accomplish sustained release, the ingredient may be modified toallow for a lower concentration of the ingredient to be released over alonger period of time versus the release of a higher concentration ofthe ingredient over a shorter period of time. A sustained release of aningredient may be advantageous in situations when the ingredient has abitter or other bad taste at the higher concentrations. A sustainedrelease of an ingredient also may be advantageous when release of theingredient in higher concentrations over a shorter period of time mayresult in a lesser amount of the ingredient being optimally delivered tothe consumer. For example, for a tooth whitening or breath fresheningingredient, providing too much of the ingredient too fast may result ina consumer swallowing a significant portion of the ingredient before theingredient has had a chance to interact with the consumer's teeth,mucous membranes, and/or dental work, thereby wasting the ingredient orat least reducing the benefit of having the ingredient in the chewinggum composition.

In some embodiments described herein, the second region of the chewinggum composition may include at least one modified release component. Atleast one modified release component optionally may be added to thefirst region composition and/or coating, as well. The additionalmodified release component that may be included in the first regioncomposition and/or coating may be the same as or different from themodified release component contained in the second region.

Flavorants

In some embodiments, flavorants may include those flavors known to theskilled artisan, such as natural and artificial flavors. Theseflavorings may be chosen from synthetic flavor oils and flavoringaromatics and/or oils, oleoresins and extracts derived from plants,leaves, flowers, fruits, and so forth, and combinations thereof.Nonlimiting representative flavor oils include spearmint oil, cinnamonoil, oil of wintergreen (methyl salicylate), peppermint oil, Japanesemint oil, clove oil, bay oil, anise oil, eucalyptus oil, thyme oil,cedar leaf oil, oil of nutmeg, allspice, oil of sage, mace, oil ofbitter almonds, and cassia oil. Also useful flavorings are artificial,natural and synthetic fruit flavors such as vanilla, and citrus oilsincluding lemon, orange, lime, grapefruit, yazu, sudachi, and fruitessences including apple, pear, peach, grape, blueberry, strawberry,raspberry, cherry, plum, pineapple, apricot, banana, melon, apricot,ume, cherry, raspberry, blackberry, tropical fruit, mango, mangosteen,pomegranate, papaya and so forth. Other potential flavors whose releaseprofiles can be managed include a milk flavor, a butter flavor, a cheeseflavor, a cream flavor, and a yogurt flavor; a vanilla flavor; tea orcoffee flavors, such as a green tea flavor, a oolong tea flavor, a teaflavor, a cocoa flavor, a chocolate flavor, and a coffee flavor; mintflavors, such as a peppermint flavor, a spearmint flavor, and a Japanesemint flavor; spicy flavors, such as an asafetida flavor, an ajowanflavor, an anise flavor, an angelica flavor, a fennel flavor, anallspice flavor, a cinnamon flavor, a camomile flavor, a mustard flavor,a cardamom flavor, a caraway flavor, a cumin flavor, a clove flavor, apepper flavor, a coriander flavor, a sassafras flavor, a savory flavor,a Zanthoxyli Fructus flavor, a perilla flavor, a juniper berry flavor, aginger flavor, a star anise flavor, a horseradish flavor, a thymeflavor, a tarragon flavor, a dill flavor, a capsicum flavor, a nutmegflavor, a basil flavor, a marjoram flavor, a rosemary flavor, a bayleafflavor, and a wasabi (Japanese horseradish) flavor; alcoholic flavors,such as a wine flavor, a whisky flavor, a brandy flavor, a rum flavor, agin flavor, and a liqueur flavor; floral flavors; and vegetable flavors,such as an onion flavor, a garlic flavor, a cabbage flavor, a carrotflavor, a celery flavor, mushroom flavor, and a tomato flavor. Theseflavoring agents may be used in liquid or solid form and may be usedindividually or in admixture. Commonly used flavors include mints suchas peppermint, menthol, spearmint, artificial vanilla, cinnamonderivatives, and various fruit flavors, whether employed individually orin admixture. Flavors may also provide breath freshening properties,particularly the mint flavors when used in combination with the coolingagents, described herein below.

In some embodiments, other flavorings include aldehydes and esters suchas cinnamyl acetate, cinnamaldehyde, citral diethylacetal, dihydrocarvylacetate, eugenyl formate, p-methylamisol, and so forth may be used.Generally any flavoring or food additive such as those described inChemicals Used in Food Processing, publication 1274, pages 63-258, bythe National Academy of Sciences, may be used. This publication isincorporated herein by reference. These may include natural as well assynthetic flavors.

Further examples of aldehyde flavorings include but are not limited toacetaldehyde (apple), benzaldehyde (cherry, almond), anisic aldehyde(licorice, anise), cinnamic aldehyde (cinnamon), citral, i.e.,alpha-citral (lemon, lime), neral, i.e., beta-citral (lemon, lime),decanal (orange, lemon), ethyl vanillin (vanilla, cream), heliotrope,i.e., piperonal (vanilla, cream), vanillin (vanilla, cream), alpha-amylcinnamaldehyde (spicy fruity flavors), butyraldehyde (butter, cheese),valeraldehyde (butter, cheese), citronellal (modifies, many types),decanal (citrus fruits), aldehyde C-8 (citrus fruits), aldehyde C-9(citrus fruits), aldehyde C-12 (citrus fruits), 2-ethyl butyraldehyde(berry fruits), hexenal, i.e., trans-2 (berry fruits), tolyl aldehyde(cherry, almond), veratraldehyde (vanilla), 2,6-dimethyl-5-heptenal, e.,melonal (melon), 2,6-dimethyloctanal (green fruit), and 2-dodecenal(citrus, mandarin), cherry, grape, blueberry, blackberry, strawberryshortcake, and mixtures thereof.

In some embodiments, flavoring agents are used at levels that provide aperceptible sensory experience i.e. at or above their threshold levels.In other embodiments, flavoring agents are used at levels below theirthreshold levels such that they do not provide an independentperceptible sensory experience. At subthreshold levels, the flavoringagents may provide an ancillary benefit such as flavor enhancement orpotentiation.

In some embodiments, a flavoring agent may be employed in either liquidform and/or dried form. When employed in the latter form, suitabledrying means such as spray drying the liquid may be used. Alternatively,the flavoring agent may be absorbed onto water soluble materials, suchas cellulose, starch, sugar, maltodextrin, gum arabic and so forth ormay be encapsulated. In still other embodiments, the flavoring agent maybe adsorbed onto silicas, zeolites, and the like.

In some embodiments, the flavoring agents may be used in many distinctphysical forms. Without being limited thereto, such physical formsinclude free forms, such as spray dried, powdered, beaded forms,encapsulated forms, and mixtures thereof.

Illustrations of the encapsulation of favors as well as other additionalcomponents can be found in the examples provided herein. Typically,encapsulation of a component will result in a delay in the release ofthe predominant amount of the component during consumption of aconfectionery composition that includes the encapsulated component(e.g., as part of a delivery system added as an ingredient to thechewing confectionery compositions). In some embodiments, the releaseprofile of the ingredient (e.g., the flavor, sweetener, etc.) can bemanaged by managing various characteristics of the ingredient, deliverysystem containing the ingredient, and/or the confectionery compositioncontaining the delivery system and/or how the delivery system is made.For example, characteristics might include one or more of the following:tensile strength of the delivery system, water solubility of theingredient, water solubility of the encapsulating material, watersolubility of the delivery system, ratio of ingredient to encapsulatingmaterial in the delivery system, average or maximum particle size ofingredient, average or maximum particle size of ground delivery system,the amount of the ingredient or the delivery system in the confectionerycomposition, ratio of different polymers used to encapsulate one or moreingredients, hydrophobicity of one or more polymers used to encapsulateone or more ingredients, hydrophobicity of the delivery system, the typeor amount of coating on the delivery system, the type or amount ofcoating on an ingredient prior to the ingredient being encapsulated,etc.

Sweetening Ingredients

Sweeteners can include sugars, sugarless bulk sweeteners, or the like,high intensity sweeteners, or mixtures thereof. Bulk sweetenersgenerally are present in amounts of about 5% to about 99% by weight ofthe confectionery or chewing gum base composition. Suitable sugarsweeteners generally include mono-saccharides, di-saccharides andpoly-saccharides such as but not limited to, sucrose (sugar), dextrose,maltose, dextrin, xylose, ribose, glucose, mannose, galactose, fructose(levulose), invert sugar, sucromalt, corn syrups, maltodextrins, oligosaccharide syrups, fructo oligo saccharide syrups, partially hydrolyzedstarch, corn syrup solids, resistant starches, and mixtures thereof.

Suitable sugarless bulk sweeteners include sugar alcohols (or polyols)such as, but not limited to, sorbitol, xylitol, mannitol, galactitol,maltitol, hydrogenated isomaltulose (ISOMALT), lactitol, erythritol,hydrogenated starch hydrolysates, and mixtures thereof.

Suitable hydrogenated starch hydrolysates include those disclosed inU.S. Pat. No., 4,279,931 and various hydrogenated glucose syrups and/orpowders which contain sorbitol, hydrogenated disaccharides, hydrogenatedhigher polysaccharides, or mixtures thereof. Hydrogenated starchhydrolysates are primarily prepared by the controlled catalytichydrogenation of corn syrups. The resulting hydrogenated starchhydrolysates are mixtures of monomeric, dimeric, and polymericsaccharides. The ratios of these different saccharides give differenthydrogenated starch hydrolysates different properties. Mixtures ofhydrogenated starch hydrolysates, such as LYCASIN®, a commerciallyavailable product manufactured by Roquette Freres of France, andHYSTAR®, a commercially available product manufactured by SPI Polyols,Inc. of New Castle, Del., are also useful.

In some embodiments, high-intensity sweeteners also may be included assweetening agents in the compositions. Without being limited toparticular sweeteners, representative categories and examples include:

(a) water-soluble sweetening agents such as dihydrochalcones, monellin,steviosides, lo han quo, glycyrrhizin, dihydroflavenol, and sugaralcohols such as sorbitol, mannitol, maltitol, xylitol, erythritol, andL-aminodicarboxylic acid aminoalkenoic acid ester amides, such as thosedisclosed in U.S. Pat. No. 4,619,834, which disclosure is incorporatedherein by reference, and mixtures thereof;

(b) water-soluble artificial sweeteners such as soluble saccharin salts,i.e., sodium or calcium saccharin salts, cyclamate salts, the sodium,ammonium or calcium salt of3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide, the potassiumsalt of 3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide(Acesulfame-K), the free acid form of saccharin, and mixtures thereof;

(c) dipeptide based sweeteners, such as L-aspartic acid derivedsweeteners, such as L-aspartyl-L-phenylalanine methyl ester (Aspartame),N—[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester(Neotame), and materials described in U.S. Pat. No. 3,492,131,L-alphaaspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-D-alaninamidehydrate (Alitame), methyl esters of L-aspartyl-L-phenylglycerine andL-aspartyl-L-2,5-dihydrophenyl-glycine,L-aspartyl-2,5-dihydro-L-phenylalanine;L-aspartyl-L-(1-cyclohexen)-alanine, and mixtures thereof;

(d) water-soluble sweeteners derived from naturally occurringwater-soluble sweeteners, such as chlorinated derivatives of ordinarysugar (sucrose), e.g., chlorodeoxysugar derivatives such as derivativesof chlorodeoxysucrose or chlorodeoxygalactosucrose, known, for example,under the product designation of Sucralose or Splenda®; examples ofchlorodeoxysucrose and chlorodeoxygalactosucrose derivatives include butare not limited to: 1-chloro-1′-deoxysucrose;4-chloro-4-deoxy-alpha-D-galactopyranosyl-alpha-D-fructofuranoside, or4-chloro-4-deoxygalactosucrose;4-chloro-4-deoxy-alpha-D-galactopyranosyl-1-chloro-1-deoxy-beta-D-fructo-furanoside,or 4,1′-dichloro-4,1′-dideoxygalactosucrose;1′,6′-dichloro-1′,6′-dideoxysucrose;4-chloro-4-deoxy-alpha-D-galactopyranosyl-1,6-dichloro-1,6-dideoxy-beta-D-fructofuranoside,or 4,1′,6′-trichloro-4,1′,6′-trideoxygalactosucrose;4,6-dichloro-4,6-dideoxy-alpha-D-galactopyranosyl-6-chloro-6-deoxy-beta-D-fructofuranoside,or 4,6,6′-trichloro-4,6,6′-trideoxygalactosucrose;6,1′,6′-trichloro-6,1′,6′-trideoxysucrose;4,6-dichloro-4,6-dideoxy-alpha-D-galacto-pyranosyl-1,6-dichloro-1,6-dideoxy-beta-D-fructofuranoside,or 4,6,1′,6′-tetrachloro4,6,1′,6′-tetradeoxygalacto-sucrose; and4,6,1′,6′-tetradeoxy-sucrose, and mixtures thereof;

(e) protein based sweeteners such as thaumaoccous danielli (Thaumatin Iand II) and talin;

(f) the sweetener monatin(2-hydroxy-2-(indol-3-ylmethyl)-4-aminoglutaric acid) and itsderivatives; and

(g) the sweetener Lo han guo (sometimes also referred to as “Lo hankuo”).

The intense sweetening agents may be used in many distinct physicalforms well-known in the art to provide an initial burst of sweetnessand/or a prolonged sensation of sweetness. Without being limitedthereto, such physical forms include free forms, spray dried forms,powdered forms, beaded forms, encapsulated forms, and mixtures thereof.In one embodiment, the sweetener is a high intensity sweetener such asaspartame, sucralose, and acesulfame potassium (e.g., Ace-K oracesulfame-K).

In some embodiments, the sweetener may be a polyol. Polyols can include,but are not limited to glycerol, sorbitol, maltitol, maltitol syrup,mannitol, isomalt, erythritol, xylitol, hydrogenated starchhydrolysates, polyglycitol syrups, polyglycitol powders, lactitol, andcombinations thereof.

The active component (e.g., sweetener), which is part of the deliverysystem, may be used in amounts necessary to impart the desired effectassociated with use of the active component (e.g., sweetness). Ingeneral, an effective amount of intense sweetener may be utilized toprovide the level of sweetness desired, and this amount may vary withthe sweetener selected. The intense sweetener may be present in amountsfrom about 0.001% to about 3%, by weight of the composition, dependingupon the sweetener or combination of sweeteners used. The exact range ofamounts for each type of sweetener may be selected by those skilled inthe art.

Sensate Ingredients

Sensate compounds can include cooling agents, warming agents, tinglingagents, effervescent agents, and combinations thereof. A variety of wellknown cooling agents may be employed. For example, among the usefulcooling agents are included xylitol, erythritol, dextrose, sorbitol,menthane, menthone, ketals, menthone ketals, menthone glycerol ketals,substituted p-menthanes, acyclic carboxamides, mono menthyl glutarate,substituted cyclohexanamides, substituted cyclohexane carboxamides,substituted ureas and sulfonamides, substituted menthanols,hydroxymethyl and hydroxymethyl derivatives of p-menthane,2-mercapto-cyclo-decanone, hydroxycarboxylic acids with 2-6 carbonatoms, cyclohexanamides, menthyl acetate, menthyl salicylate,N,2,3-trimethyl-2-isopropyl butanamide (WS-23),N-ethyl-p-menthane-3-carboxamide (WS-3), ethyl ester ofN-[[5-methyl-2-(1-methylethyl)cyclohexyl]carbonyl]glycine (WS5), as wellas the substantially pure ethyl ester ofN-[[5-methyl-2-(1-methylethyl)cyclohexyl]carbonyl]glycine as disclosedin U.S. Pat. No. 7,189,760 to Erman, et al which is incorporated in itsentirety herein by reference, isopulegol, menthyloxy propane diol,3-(1-menthoxy)propane-1,2-diol, 3-(1-menthoxy)-2-methylpropane-1,2-diol,p-menthane-2,3-diol, p-menthane-3,8-diol,6-isopropyl-9-methyl-1,4-dioxaspiro[4,5]decane-2-methanol, menthylsuccinate and its alkaline earth metal salts, trimethylcyclohexanol,N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide, Japanese mint oil,peppermint oil, 3-(1-menthoxy)ethan-1-ol, 3-(1-menthoxy)propan-1-ol,3-(1-menthoxy)butan-1-ol, 1-menthylacetic acid N-ethylamide,1-menthyl-4-hydroxypentanoate, 1-menthyl-3-hydroxybutyrate,N,2,3-trimethyl-2-(1-methylethyl)-butanamide, n-ethyl-t-2-c-6nonadienamide, N,N-dimethyl menthyl succinamide, substitutedp-menthanes, substituted p-menthane-carboxamides,2-isopropanyl-5-methylcyclohexanol (from Hisamitsu Pharmaceuticals,hereinafter “isopregol”); menthone glycerol ketals (FEMA 3807, tradenameFRESCOLAT® type MGA); 3-1-menthoxypropane-1,2-diol (from Takasago, FEMA3784); and menthyl lactate; (from Haarman & Reimer, FEMA 3748, tradenameFRESCOLAT® type ML), WS-30, WS-14, Eucalyptus extract(p-Mentha-3,8-Diol), Menthol (its natural or synthetic derivatives),Menthol PG carbonate, Menthol EG carbonate, Menthol glyceryl ether,N-tertbutyl-p-menthane-3-carboxamide, P-menthane-3-carboxylic acidglycerol ester, Methyl-2-isopryl-bicyclo(2.2.1), Heptane-2-carboxamide;Menthol methyl ether, menthyl pyrrolidone carboxylate;2,5-dimethyl-4-(1-pyrrolidinyl)-3(2H)-furanone; cyclic α-keto enamines,cyclotene derivatives such as cyclopentenes including3-methyl-2-(1-pyrrolidinyl)-2-cyclopenten-1-one and5-methyl-2-(1-pyrrolidinyl)-2-cyclopenten-1-one, compounds of theformula:

wherein B is selected from H, CH3, C2H5, OCH3, 0C2H5; and OH; andwherein A is a moiety of the formula-CO-D, wherein D is selected fromthe following moieties: (i) —NR1R2, wherein R′ and R2 are independentlyselected from H and C1-C8 straight or branched-chain aliphatic,alkoxyalkyl, hydroxyalkyl, araliphatic and cycloalkyl groups, or R1 andR2 together with the nitrogen atom to which they are attached form, partof an optionally-substituted, five- or six-membered heterocyclic ring;(ii) —NIICH2COOCH2CH3, —NHCH2CONH2, —NHCH2CH2OCH3, —NHCH2CH2OH,—NHCH2CH(OH)CH2OH and (iii) a moiety selected from the group consistingof:

as disclosed in PCT Patent Application WO2006/125334 to Bell et al whichis incorporated in its entirety herein by reference, among others. Othercompounds include the alpha-keto enamines disclosed in U.S. Pat. No.6,592,884 to Hofmann et al which is incorporated in its entirety hereinby reference. These and other suitable cooling agents are furtherdescribed in the following U.S. patents, all of which are incorporatedin their entirety by reference hereto: U.S. Pat. Nos. 4,230,688;4,032,661; 4,459,425; 4,178,459; 4,296,255; 4,136,163; 5,009,893;5,266,592; 5,698,181; 6,277,385; 6,627,233; 7,030,273. Still othersuitable cooling agents are further described in the following U.S.patent applications, all of which are incorporated in their entirety byreference hereto: U.S. 2005/0222256; 2005/0265930.

In some embodiments, warming components may be selected from a widevariety of compounds known to provide the sensory signal of warming tothe user. These compounds offer the perceived sensation of warmth,particularly in the oral cavity, and often enhance the perception offlavors, sweeteners and other organoleptic components. In someembodiments, useful warming compounds can include vanillyl alcoholn-butylether (TK-1000) supplied by Takasago Perfumary Company Limited,Tokyo, Japan, vanillyl alcohol n-propylether, vanillyl alcoholisopropylether, vanillyl alcohol isobutylether, vanillyl alcoholn-aminoether, vanillyl alcohol isoamyleather, vanillyl alcoholn-hexyleather, vanillyl alcohol methylether, vanillyl alcoholethylether, gingerol, shogaol, paradol, zingerone, capsaicin,dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin,homodihydrocapsaicin, ethanol, isopropyl alcohol, iso-amylalcohol,benzyl alcohol, glycerine, and combinations thereof.

In some embodiments, a tingling sensation can be provided. One suchtingling sensation is provided by adding jambu, oleoresin, or spilantholto some examples. In some embodiments, alkylamides extracted frommaterials such as jambu or sanshool can be included. Additionally, insome embodiments, a sensation is created due to effervescence. Sucheffervescence is created by combining an alkaline material with anacidic material. In some embodiments, an alkaline material can includealkali metal carbonates, alkali metal bicarbonates, alkaline earth metalcarbonates, alkaline earth metal bicarbonates and mixtures thereof. Insome embodiments, an acidic material can include acetic acid, adipicacid, ascorbic acid, butyric acid, citric acid, formic acid, fumaricacid, glyconic acid, lactic acid, phosphoric acid, malic acid, oxalicacid, succinic acid, tartaric acid, aspartic acid, benzoic acid,caffeotannic acid, iso-citric acid, citramalic acid, galacturonic acid,glucuronic acid, glyceric acid, glycolic acid, ketoglutaric acid,a-ketoglutaric acid, lactoisocitric acid, oxalacetic acid, pyruvic acid,quinic acid, shikimic acid, succinic acid, tannic acid, hydroxyaceticacid, suberic acid, sebacic acid, azelaic acid, pimelic acid, capriccid, and combinations thereof. Examples of “tingling” type sensates canbe found in U.S. Pat. No. 6,780,443, the entire contents of which areincorporated herein by reference for all purposes.

Sensate components may also be referred to as “trigeminal stimulants”such as those disclosed in U.S. Patent Application No. 2005/0202118,which is incorporated herein by reference. Trigeminal stimulants aredefined as an orally consumed product or agent that stimulates thetrigeminal nerve. Examples of cooling agents which are trigeminalstimulants include menthol, WS-3, N-substituted p-menthane carboxamide,acyclic carboxamides including WS-23, WS-5, WS-14, methyl succinate, andmenthone glycerol ketals. Trigeminal stimulants can also includeflavors, tingling agents, Jambu extract, vanillyl alkyl ethers, such asvanillyl n-butyl ether, spilanthol, Echinacea extract, Northern PricklyAsh extract, capsaicin, capsicum oleoresin, red pepper oleoresin, blackpepper oleoresin, piperine, ginger oleoresin, gingerol, shoagol,cinnamon oleoresin, cassia oleoresin, cinnamic aldehyde, eugenol, cyclicacetal of vanillin and menthol glycerin ether, unsaturated amides, andcombinations thereof. Other cooling compounds can include derivatives of2,3-dimethyl-2-isopropylbutyric acid such as those disclosed in U.S.Pat. No. 7,030,273, which is incorporated herein by reference.

In addition to trigeminal nerve stimulants and cooling compounds, acooling sensation can be provided by materials exhibiting a negativeheat of solution including, but not limited to, polyols such as xylitol,erythritol, dextrose, and sorbitol, and combinations thereof.

In some embodiments, sensate components are used at levels that providea perceptible sensory experience i.e. at or above their thresholdlevels. In other embodiments, sensate components are used at levelsbelow their threshold levels such that they do not provide anindependent perceptible sensory experience. At subthreshold levels, thesensates may provide an ancillary benefit such as flavor or sweetnessenhancement or potentiation.

Breath Freshening Ingredients

Breath fresheners can include essential oils as well as variousaldehydes, alcohols, and similar materials. In some embodiments,essential oils can include oils of spearmint, peppermint, wintergreen,sassafras, chlorophyll, citral, geraniol, cardamom, clove, sage,carvacrol, eucalyptus, cardamom, magnolia bark extract, marjoram,cinnamon, lemon, lime, grapefruit, and orange. In some embodiments,aldehydes such as cinnamic aldehyde and salicylaldehyde can be used.Additionally, chemicals such as menthol, carvone, iso-garrigol, andanethole can function as breath fresheners. Of these, the most commonlyemployed are oils of peppermint, spearmint and chlorophyll.

In addition to essential oils and chemicals derived from them, in someembodiments breath fresheners can include but are not limited to zinccitrate, zinc acetate, zinc fluoride, zinc ammonium sulfate, zincbromide, zinc iodide, zinc chloride, zinc nitrate, zinc flurosilicate,zinc gluconate, zinc, tartarate, zinc succinate, zinc formate, zincchromate, zinc phenol sulfonate, zinc dithionate, zinc sulfate, silvernitrate, zinc salicylate, zinc glycerophosphate, copper nitrate,chlorophyll, copper chlorophyll, chlorophyllin, hydrogenated cottonseedoil, chlorine dioxide, beta cyclodextrin, zeolite, silica-basedmaterials, carbon-based materials, enzymes such as laccase, andcombinations thereof.

In some embodiments, the release profiles of probiotics can be managedfor a confectionery including, but not limited to lactic acid producingmicroorganisms such as Bacillus coagulans, Bacillus subtilis, Bacilluslaterosporus, Bacillus laevolacticus, Sporolactobacillus inulinus,Lactobacillus acidophilus, Lactobacillus curvatus, Lactobacillusplantarum, Lactobacillus jenseni, Lactobacillus casei, Lactobacillusfermentum, Lactococcus lactis, Pedioccocus acidilacti, Pedioccocuspentosaceus, Pedioccocus urinae, Leuconostoc mesenteroides, Bacilluscoagulans, Bacillus subtilis, Bacillus laterosporus, Bacilluslaevolacticus, Sporolactobacillus inulinus and mixtures thereof. Breathfresheners are also known by the following trade names: Retsyn,™Actizol,™ and Nutrazin.™ Examples of malodor-controlling compositionsare also included in U.S. Pat. No. 5,300,305 to Stapler et al. and inU.S. Patent Application Publication Nos. 2003/0215417 and 2004/0081713which are incorporated in their entirety herein by reference for allpurposes.

Dental Care Ingredients

Dental care ingredients (also known as oral care ingredients) mayinclude but are not limited to tooth whiteners, stain removers, oralcleaning, bleaching agents, desensitizing agents, dentalremineralization agents, antibacterial agents, anticaries agents, plaqueacid buffering agents, surfactants and anticalculus agents. Non-limitingexamples of such ingredients can include, hydrolytic agents includingproteolytic enzymes, abrasives such as hydrated silica, calciumcarbonate, sodium bicarbonate and alumina, other active stain-removingcomponents such as surface-active agents, including, but not limited toanionic surfactants such as sodium stearate, sodium palminate, sulfatedbutyl oleate, sodium oleate, salts of fumaric acid, glycerolhydroxylated lecithin, sodium lauryl sulfate and chelators such aspolyphosphates, which are typically employed as tartar controlingredients. In some embodiments, dental care ingredients can alsoinclude tetrasodium pyrophosphate and sodium tri-polyphosphate, sodiumbicarbonate, sodium acid pyrophosphate, sodium tripolyphosphate,xylitol, sodium hexametaphosphate.

In some embodiments, peroxides such as carbamide peroxide, calciumperoxide, magnesium peroxide, sodium peroxide, hydrogen peroxide, andperoxydiphospate are included. In some embodiments, potassium nitrateand potassium citrate are included. Other examples can include caseinglycomacropeptide, calcium casein peptone-calcium phosphate, caseinphosphopeptides, casein phosphopeptide-amorphous calcium phosphate(CPP-ACP), and amorphous calcium phosphate. Still other examples caninclude papaine, krillase, pepsin, trypsin, lysozyme, dextranase,mutanase, glycoamylase, amylase, glucose oxidase, and combinationsthereof.

Further examples can include surfactants such as sodium stearate, sodiumricinoleate, and sodium lauryl sulfate surfactants for use in someembodiments to achieve increased prophylactic action and to render thedental care ingredients more cosmetically acceptable. Surfactants canpreferably be detersive materials which impart to the compositiondetersive and foaming properties. Suitable examples of surfactants arewater-soluble salts of higher fatty acid monoglyceride monosulfates,such as the sodium salt of the monosulfated monoglyceride ofhydgrogenated coconut oil fatty acids, higher alkyl sulfates such assodium lauryl sulfate, alkyl aryl sulfonates such as sodium dodecylbenzene sulfonate, higher alkyl sulfoacetates, sodium laurylsulfoacetate, higher fatty acid esters of 1,2-dihydroxy propanesulfonate, and the substantially saturated higher aliphatic acyl amidesof lower aliphatic amino carboxylic acid compounds, such as those having12 to 16 carbons in the fatty acid, alkyl or acyl radicals, and thelike. Examples of the last mentioned amides are N-lauroyl sarcosine, andthe sodium, potassium, and ethanolamine salts of N-lauroyl, N-myristoyl,or N-palmitoyl sarcosine.

In addition to surfactants, dental care ingredients can includeantibacterial agents such as, but not limited to, triclosan,chlorhexidine, zinc citrate, silver nitrate, copper, limonene, and cetylpyridinium chloride. In some embodiments, additional anticaries agentscan include fluoride ions or fluorine-providing components such asinorganic fluoride salts. In some embodiments, soluble alkali metalsalts, for example, sodium fluoride, potassium fluoride, sodiumfluorosilicate, ammonium fluorosilicate, sodium monofluorophosphate, aswell as tin fluorides, such as stannous fluoride and stannous chloridecan be included. In some embodiments, a fluorine-containing compoundhaving a beneficial effect on the care and hygiene of the oral cavity,e.g., diminution of enamel solubility in acid and protection of theteeth against decay may also be included as an ingredient Examplesthereof include sodium fluoride, stannous fluoride, potassium fluoride,potassium stannous fluoride (SnF.sub.2-KF), sodium hexafluorostannate,stannous chlorofluoride, sodium fluorozirconate, and sodiummonofluorophosphate. In some embodiments, urea is included.

Further examples are included in the following U.S. patents and U.S.published patent applications, the contents of all of which areincorporated in their entirety herein by reference for all purposes:U.S. Pat. Nos. 5,227,154 to Reynolds, 5,378,131 to Greenberg, 6,846,500to Luo et al., 6,733,818 to Luo et al., 6,696,044 to Luo et al.,6,685,916 to Holme et al., 6,485,739 to Luo et al., 6,479,071 to Holmeet al., 6,471,945 to Luo et al., U.S. Patent Publication Nos.20050025721 to Holme et al., 2005008732 to Gebreselassie et al., and20040136928 to Holme et al.

Active Ingredients

Actives generally refer to those ingredients that are included in adelivery system and/or confectionery composition for the desired endbenefit they provide to the user. In some embodiments, actives caninclude medicaments, nutrients, nutraceuticals, herbals, nutritionalsupplements, pharmaceuticals, drugs, and the like and combinationsthereof.

Examples of useful drugs include ace-inhibitors, antianginal drugs,anti-arrhythmias, anti-asthmatics, anti-cholesterolemics, analgesics,anesthetics, anti-convulsants, anti-depressants, anti-diabetic agents,anti-diarrhea preparations, antidotes, anti-histamines,anti-hypertensive drugs, anti-inflammatory agents, anti-lipid agents,anti-manics, anti-nauseants, anti-stroke agents, anti-thyroidpreparations, anti-tumor drugs, anti-viral agents, acne drugs,alkaloids, amino acid preparations, anti-tussives, anti-uricemic drugs,anti-viral drugs, anabolic preparations, systemic and non-systemicanti-infective agents, anti-neoplastics, anti-parkinsonian agents,anti-rheumatic agents, appetite stimulants, biological responsemodifiers, blood modifiers, bone metabolism regulators, cardiovascularagents, central nervous system stimulates, cholinesterase inhibitors,contraceptives, decongestants, dietary supplements, dopamine receptoragonists, endometriosis management agents, enzymes, erectile dysfunctiontherapies such as sildenafil citrate, which is currently marketed asViagra™, fertility agents, gastrointestinal agents, homeopathicremedies, hormones, hypercalcemia and hypocalcemia management agents,immunomodulators, immunosuppressives, migraine preparations, motionsickness treatments, muscle relaxants, obesity management agents,osteoporosis preparations, oxytocics, parasympatholytics,parasympathomimetics, prostaglandins, psychotherapeutic agents,respiratory agents, sedatives, smoking cessation aids such asbromocryptine or nicotine, sympatholytics, tremor preparations, urinarytract agents, vasodilators, laxatives, antacids, ion exchange resins,anti-pyretics, appetite suppressants, expectorants, anti-anxiety agents,anti-ulcer agents, anti-inflammatory substances, coronary dilators,cerebral dilators, peripheral vasodilators, psycho-tropics, stimulants,anti-hypertensive drugs, vasoconstrictors, migraine treatments,antibiotics, tranquilizers, anti-psychotics, anti-tumor drugs,anti-coagulants, anti-thrombotic thrombotic drugs, hypnotics,anti-emetics, anti-nauseants, anti-convulsants, neuromuscular drugs,hyper- and hypo-glycemic agents, thyroid and anti-thyroid preparations,diuretics, anti-spasmodics, terine relaxants, anti-obesity drugs,erythropoietic drugs, anti-asthmatics, cough suppressants, mucolytics,DNA and genetic modifying drugs, and combinations thereof.

Examples of active ingredients contemplated for use in some embodimentscan include antacids, H2-antagonists, and analgesics. For example,antacid dosages can be prepared using the ingredients calcium carbonatealone or in combination with magnesium hydroxide, and/or aluminumhydroxide. Moreover, antacids can be used in combination withH2-antagonists.

Analgesics include opiates and opiate derivatives, such as Oxycontin™,ibuprofen, aspirin, acetaminophen, and combinations thereof that mayoptionally include caffeine.

Other drug active ingredients for use in embodiments can includeanti-diarrheals such as Immodium™ AD, anti-histamines, anti-tussives,decongestants, vitamins, and breath fresheners. Also contemplated foruse herein are anxiolytics such as Xanax™; anti-psychotics such asClozaril™ and Haldol™; non-steroidal anti-inflammatories (NSAID's) suchas ibuprofen, naproxen sodium, Voltaren™ and Lodine™, anti-histaminessuch as Claritin™, Hismanal™, Relafen™, and Tavist™; anti-emetics suchas Kytril™ and Cesamet™; bronchodilators such as Bentolin™, Proventil™;anti-depressants such as Prozac™, Zoloft™, and Paxil™; anti-migrainessuch as Imigra™, ACE-inhibitors such as Vasotec™, Capoten™ and Zestril™;anti-Alzheimer's agents, such as Nicergoline™; and CaH-antagonists suchas Procardia™, Adalat™, and Calan™.

The popular H2-antagonists which are contemplated for use in the presentinvention include cimetidine, ranitidine hydrochloride, famotidine,nizatidien, ebrotidine, mifentidine, roxatidine, pisatidine andaceroxatidine.

Active antacid ingredients can include, but are not limited to, thefollowing: aluminum hydroxide, dihydroxyaluminum aminoacetate,aminoacetic acid, aluminum phosphate, dihydroxyaluminum sodiumcarbonate, bicarbonate, bismuth aluminate, bismuth carbonate, bismuthsubcarbonate, bismuth subgallate, bismuth subnitrate, bismuthsubsilysilate, calcium carbonate, calcium phosphate, citrate ion (acidor salt), amino acetic acid, hydrate magnesium aluminate sulfate,magaldrate, magnesium aluminosilicate, magnesium carbonate, magnesiumglycinate, magnesium hydroxide, magnesium oxide, magnesium trisilicate,milk solids, aluminum mono-ordibasic calcium phosphate, tricalciumphosphate, potassium bicarbonate, sodium tartrate, sodium bicarbonate,magnesium aluminosilicates, tartaric acids and salts.

A variety of nutritional supplements may also be used as activeingredients including virtually any vitamin or mineral. For example,vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, vitamin B₆,vitamin B₁₂, thiamine, riboflavin, biotin, folic acid, niacin,pantothenic acid, sodium, potassium, calcium, magnesium, phosphorus,sulfur, chlorine, iron, copper, iodine, zinc, selenium, manganese,choline, chromium, molybdenum, fluorine, cobalt and combinations thereofmay be used.

Examples of nutritional supplements that can be used as activeingredients are set forth in U.S. Patent Application Publication Nos.2003/0157213 A1, 2003/0206993 and 2003/0099741 A1 which are incorporatedin their entirety herein by reference for all purposes.

Various herbals may also be used as active ingredients such as thosewith various medicinal or dietary supplement properties. Herbals aregenerally aromatic plants or plant parts and or extracts thereof thatcan be used medicinally or for flavoring. Suitable herbals can be usedsingly or in various mixtures. Commonly used herbs include Echinacea,Goldenseal, Calendula, Rosemary, Thyme, Kava Kava, Aloe, Blood Root,Grapefruit Seed Extract, Black Cohosh, Ginseng, Guarana, Cranberry,Gingko Biloba, St. John's Wort, Evening Primrose Oil, Yohimbe Bark,Green Tea, Ma Huang, Maca, Bilberry, Lutein, and combinations thereof.

Effervescing System Ingredients

An effervescent system may include one or more edible acids and one ormore edible alkaline materials. The edible acid(s) and the ediblealkaline material(s) may react together to generate effervescence.

In some embodiments, the alkaline material(s) may be selected from, butis not limited to, alkali metal carbonates, alkali metal bicarbonates,alkaline earth metal carbonates, alkaline earth metal bicarbonates, andcombinations thereof. The edible aced(s) may be selected from, but isnot limited to, citric acid, phosphoric acid, tartaric acid, malic acid,ascorbic acid, and combinations thereof. In some embodiments, aneffervescing system may include one or more other ingredients such as,for example, carbon dioxide, oral care ingredients, flavorants, etc.

For examples of use of an effervescing system in a chewingconfectionery, refer to U.S. Provisional Patent No. 60/618,222 filedOct. 3, 2004, and entitled “Effervescent Pressed Confectionery TabletCompositions,” the contents of which are incorporated herein byreference for all purposes. Other examples can be found in U.S. Pat. No.6,235,318, the contents of which are incorporated herein by referencefor all purposes.

Appetite Suppressor Ingredients

Appetite suppressors can be ingredients such as fiber and protein thatfunction to depress the desire to consume food. Appetite suppressors canalso include benzphetamine, diethylpropion, mazindol, phendimetrazine,phentermine, hoodia (P57), Olibra,™ ephedra, caffeine and combinationsthereof. Appetite suppressors are also known by the following tradenames: Adipex,™ Adipost,™ Bontril™ PDM, Bontril™ Slow Release, Didrex,™Fastin,™ Ionamin,™ Mazanor,™ Melfiat,™ Obenix,™ Phendiet,™Phendiet-105,™ Phentercot,™ Phentride,™ Plegine,™ Prelu-2,™ Pro-Fast,™PT 105,™ Sanorex,™ Tenuate,™ Sanorex,™ Tenuate,™ Tenuate Dospan,™Tepanil Ten-Tab,™ Teramine,™ and Zantryl.™ These and other suitableappetite suppressors are further described in the following U.S.patents, all of which are incorporated in their entirety by referencehereto: U.S. Pat. No. 6,838,431 to Portman, U.S. Pat. No. 6,716,815 toPortman, U.S. Pat. No. 6,558,690 to Portman, U.S. Pat. No. 6,468,962 toPortman, U.S. Pat. No. 6,436,899 to Portman.

Potentiator Ingredients

Potentiators can consist of materials that may intensify, supplement,modify or enhance the taste and/or aroma perception of an originalmaterial without introducing a characteristic taste and/or aromaperception of their own. In some embodiments, potentiators designed tointensify, supplement, modify, or enhance the perception of flavor,sweetness, tartness, umami, kokumi, saltiness and combinations thereofcan be included.

In some embodiments, examples of suitable potentiators, also known astaste potentiators include, but are not limited to, neohesperidindihydrochalcone, optically active S-alkyl 2-methyl butane thioatecompounds such as those disclosed in PCT Application Number WO2007/032262 to Ogura et al, which is incorporated in its entirety hereinby reference, chlorogenic acid, alapyridaine, cynarin, miraculin,glupyridaine, pyridinium-betain compounds, glutamates, such asmonosodium glutamate and monopotassium glutamate, neotame, thaumatin,tagatose, trehalose, salts, such as sodium chloride, monoammoniumglycyrrhizinate, vanilla extract (in ethyl alcohol), sugar acids,potassium chloride, sodium acid sulfate, hydrolyzed vegetable proteins,hydrolyzed animal proteins, yeast extracts, adenosine monophosphate(AMP), glutathione, nucleotides, such as inosine monophosphate, disodiuminosinate, xanthosine monophosphate, guanylate monophosphate,alapyridaine (N-(1-carboxyethyl)-6-(hydroxymethyl)pyridinium-3-ol innersalt, compositions comprising 5′-nucleotides such as those disclosed inUS 2006/0078972 to Noordam et al, which is incorporated in its entiretyherein by reference, sugar beet extract (alcoholic extract), sugarcaneleaf essence (alcoholic extract), curculin, strogin, mabinlin, gymnemicacid, hydroxybenzoic acids, 3-hydrobenzoic acid, 2,4-dihydrobenzoicacid, citrus aurantium, vanilla oleoresin, sugarcane leaf essence,maltol, ethyl maltol, vanillin, licorice glycyrrhizinates, compoundsthat respond to the TRPM5 ion channel that mediates taste receptors forsweet, bitter, and savory tastes as disclosed in U.S. Patent ApplicationNumber 2005/0019830 to Penner et al, which is incorporated in itsentirety herein by reference, pyridinium betain compounds as disclosedin U.S. Pat. No. 7,175,872 to Hofmann et al, which is incorporated inits entirety herein by reference, compounds that respond to G-proteincoupled receptors (T2Rs and T1Rs) and taste potentiator compositionsthat impart kokumi, as disclosed in U.S. Pat. No. 5,679,397 to Kuroda etal., which is incorporated in its entirety herein by reference. “Kokumi”refers to materials that impart “mouthfulness” and “good body”.

Sweetener potentiators, which are a type of taste potentiator, enhancethe taste of sweetness. In some embodiments, exemplary sweetenerpotentiators include, but are not limited to, monoammoniumglycyrrhizinate, licorice glycyrrhizinates, citrus aurantium,alapyridaine, alapyridaine(N-(1-carboxyethyl)-6-(hydroxymethyl)pyridinium-3-ol) inner salt,miraculin, curculin, strogin, mabinlin, gymnemic acid, cynarin,glupyridaine, pyridinium-betain compounds, sugar beet extract, neotame,thaumatin, neohesperidin dihydrochalcone, hydroxybenzoic acids,tagatose, trehalose, gurmarin, extracts and derivatives of extracts fromGymnema sylvestre, tryptophan, maltol, ethyl maltol, vanilla extract,vanilla oleoresin, vanillin, sugar beet extract (alcoholic extract),sugarcane leaf essence (alcoholic extract), compounds that respond toG-protein coupled receptors (T2Rs and T1Rs), compounds that respond tothe human T1R2 taste receptor, and combinations thereof.

Additional examples of potentiators for the enhancement of salt tasteinclude acidic peptides, such as those disclosed in U.S. Pat. No.6,974,597, herein incorporated by reference. Acidic peptides includepeptides having a larger number of acidic amino acids, such as asparticacid and glutamic acid, than basic amino acids, such as lysine, arginineand histidine. The acidic peptides are obtained by peptide synthesis orby subjecting proteins to hydrolysis using endopeptidase, and ifnecessary, to deamidation. Suitable proteins for use in the productionof the acidic peptides or the peptides obtained by subjecting a proteinto hydrolysis and deamidation include plant proteins, (e.g. wheatgluten, corn protein (e.g., zein and gluten meal), soybean proteinisolate), animal proteins (e.g., milk proteins such as milk casein andmilk whey protein, muscle proteins such as meat protein and fish meatprotein, egg white protein and collagen), and microbial proteins (e.g.,microbial cell protein and polypeptides produced by microorganisms).

The sensation of warming or cooling effects may also be prolonged withthe use of a hydrophobic sweetener as described in U.S. PatentApplication Publication 2003/0072842 A1 which is incorporated in itsentirety herein by reference. For example, such hydrophobic sweetenersinclude those of the formulae I-XI as set forth below:

wherein X, Y and Z are selected from the group consisting of CH₂, O andS;

wherein X and Y are selected from the group consisting of S and O;

wherein X is S or O; Y is O or CH₂; Z is CH₂, SO₂ or S; R is OCH₃, OH orH, R¹ is SH or OH and R² is H or OH;

wherein X is C or S; R is OH or H and R¹ is OCH₃ or OH;

wherein R, R² and R³ are OH or H and R¹ is H or COOH;

wherein X is O or CH₂ and R is COOH or H;

wherein R is CH₃CH₂, OH, N(CH3)₂ or Cl;

Perillartine may also be added as described in U.S. Pat. No. 6,159,509also incorporated in its entirety herein by reference.

Food Acid Ingredients

Acids can include, but are, not limited to acetic acid, adipic acid,ascorbic acid, butyric acid, citric acid, formic acid, fumaric acid,glyconic acid, lactic acid, phosphoric acid, malic acid, oxalic acid,succinic acid, tartaric acid, aspartic acid, benzoic acid, caffeotannicacid, iso-citric acid, citramalic acid, galacturonic acid, glucuronicacid, glyceric acid, glycolic acid, ketoglutaric acid, a-ketoglutaricacid, lactoisocitric acid, oxalacetic acid, pyruvic acid, quinic acid,shikimic acid, succinic acid, tannic acid, hydroxyacetic acid, subericacid, sebacic acid, azelaic acid, pimelic acid, capric acid, andcombinations thereof.

Micronutrient Ingredients

Micronutrients can include materials that have an impact on thenutritional well being of an organism even though the quantity, requiredby the organism to have the desired effect is small relative tomacronutrients such as protein, carbohydrate, and fat. Micronutrientscan include, but are not limited to vitamins, minerals, enzymes,phytochemicals, antioxidants, and combinations thereof.

In some embodiments, vitamins can include fat soluble vitamins such asvitamin A, vitamin D, vitamin E, and vitamin K and combinations thereof.In some embodiments, vitamins can include water soluble vitamins such asvitamin (C (ascorbic acid), the B vitamins (thiamine or B₁, riboflavoinor B₂, niacin or B₃, pyridoxine or B₆, folic acid or B₉, cyanocobaliminor B₁₂, pantothenic acid, biotin), and combinations thereof.

In some embodiments minerals can include but are not limited to sodium,magnesium, chromium, iodine, iron, manganese, calcium, copper, fluoride,potassium, phosphorous, molybdenum, selenium, zinc, and combinationsthereof.

In some embodiments micronutrients can include but are not limited toL-carnitine, choline, coenzyme Q10, alpha-lipoic acid, omega-3-fattyacids, pepsin, phytase, trypsin, lipases, proteases, cellulases, andcombinations thereof.

Antioxidants can include materials that scavenge free radicals. In someembodiments, antioxidants can include but are not limited to ascorbicacid, citric acid, rosemary oil, vitamin A, vitamin E, vitamin Ephosphate, tocopherols, di-alpha-tocopheryl phosphate, tocotrienols,alpha lipoic acid, dihydrolipoic acid, xanthophylls, beta cryptoxanthin,lycopene, lutein, zeaxanthin, astaxanthin, beta-carotene, carotenes,mixed carotenoids, polyphenols, flavonoids, and combinations thereof.

In some embodiments phytochemicals can include but are not limited tocartotenoids, chlorophyll, chlorophyllin, fiber, flavanoids,anthocyanins, cyaniding, delphinidin, malvidin, pelargonidin, peonidin,petunidin, flavanols, catechin, epicatechin, epigallocatechin,epigallocatechingallate (EGCG), theaflavins, thearubigins,proanthocyanins, flavonols, quercetin, kaempferol, myricetin,isorhamnetin, flavononeshesperetin, naringenin, eriodictyol, tangeretin,flavones, apigenin, luteolin, lignans, phytoestrogens, resveratrol,isoflavones, daidzein, genistein, glycitein, soy isoflavones, andcombinations thereof.

Mouth Moistening Ingredients

Mouth moisteners can include, but are not limited to, saliva stimulatorssuch as acids and salts and combinations thereof. In some embodiments,acids can include acetic acid, adipic acid, ascorbic acid, butyric acid,citric acid, formic acid, fumaric acid, glyconic acid, lactic acid,phosphoric acid, malic acid, oxalic acid, succinic acid, tartaric acidand combinations thereof.

Mouth moisteners can also include hydrocolloid materials that hydrateand may adhere to oral surface to provide a sensation of mouthmoistening. Hydrocolloid materials can include naturally occurringmaterials such as plant exudates, seed gums, and seaweed extracts orthey can be chemically modified materials such as cellulose, starch, ornatural gum derivatives. In some embodiments, hydrocolloid materials caninclude pectin, gum arabic, acacia gum, alginates, agar, carageenans,guar gum, xanthan gum, locust bean gum, gelatin, gellan gum, cassia gum,galactomannans, tragacanth gum, karaya gum, curdlan, konjac, chitosan,xyloglucan, beta glucan, furcellaran, gum ghatti, tamarin, bacterialgums, and combinations thereof. Additionally, in some embodiments,modified natural gums such as propylene glycol alginate, carboxymethyllocust bean gum, low methoxyl pectin, and their combinations can beincluded. In some embodiments, modified celluloses can be included suchas microcrystalline cellulose, carboxymethlcellulose (CMC),methylcellulose (MC), hydroxypropylmethylcellulose (HPCM), andhydroxypropylcellulose (MPC), and combinations thereof.

Similarly, humectants which can provide a perception of mouth hydrationcan be included. Such humectants can include, but are not limited toglycerol, sorbitol, polyethylene glycol, erythritol, and xylitol.Additionally, in some embodiments, fats can provide a perception ofmouth moistening. Such fats can include medium chain triglycerides,vegetable oils, fish oils, mineral oils, and combinations thereof.

Mouth moisteners can also include pellitorine extracts, extracts ofAnacyclus pyrethrum, trans-pellitorin,N-isobutyl-trans-2-trans-4-decadienamide, alkadienamides includingN-isobutyl-E2, E4-decadienamide; N-isobutyl-E2, E4-undecadienamide;N-pyrollidyl-E2, E4-decadienamide; N-piperidl-E2, E4-decadienamdie, orcombinations thereof as disclosed in U.S. Patent Application No.2007/0075368 which is incorporated in its entirety herein by reference;blends of n-isobutyldeca-trans-2-trans-4-dienamide with food acids asdisclosed in U.S. Patent Application No. 2006/0204551 which isincorporated in its entirety herein by reference; blends of compoundsaccording to formula (I): wherein R₁ represents C1-C2 n-alkyl; R₂ is2-methyl-1-propyl and R₃ is hydrogen; or R₂ and R₃ taken together is amoiety having the formula —(CH₂)_(n)— wherein n is 4 or 5, or mixturesthereof with cooling compounds as disclosed in U.S. Patent ApplicationNo. 2007/0036838 to Keenan et al, which is incorporated in its entiretyherein by reference.

Throat Care Ingredients

Throat soothing ingredients can include analgesics, anesthetics,demulcents, antiseptic, and combinations thereof. In some embodiments,analgesics/anesthetics can include menthol, phenol, hexylresorcinol,benzocaine, dyclonine hydrochloride, benzyl alcohol, salicyl alcohol,and combinations thereof. In some embodiments, demulcents can includebut are not limited to slippery elm bark, pectin, gelatin, andcombinations thereof. In some embodiments, antiseptic ingredients caninclude cetylpyridinium chloride, domiphen bromide, dequaliniumchloride, and combinations thereof.

In some embodiments, antitussive ingredients such as chlophedianolhydrochloride, codeine, codeine phosphate, codeine sulfate,dextromethorphan, dextromethorphan hydrobromide, diphenhydraminecitrate, and diphenhydramine hydrochloride, and combinations thereof canbe included.

In some embodiments, throat soothing agents such as honey, propolis,aloe vera, glycerine, menthol and combinations thereof can be included.In still other embodiments, cough suppressants can be included. Suchcough suppressants can fall into two groups: those that alter theconsistency or production of phlegm such as mucolytics and expectorants;and those that suppress the coughing reflex such as codeine (narcoticcough suppressants), antihistamines, dextromethorphan and isoproterenol(non-narcotic cough suppressants). In some embodiments, ingredients fromeither or both groups can be included.

In still other embodiments, antitussives can include, but are notlimited to, the group consisting of codeine, dextromethorphan,dextrorphan, diphenhydramine, hydrocodone, noscapine, oxycodone,pentoxyverine and combinations thereof. In some embodiments,antihistamines can include, but are not limited to, acrivastine,azatadine, brompheniramine, chlorpheniramine, clemastine,cyproheptadine, dexbrompheniramine, dimenhydrinate, diphenhydramine,doxylamine, hydroxyzine, meclizine, phenindamine, phenyltoloxamine,promethazine, pyrilamine, tripelennamine, triprolidine and combinationsthereof. In some embodiments, non-sedating, antihistamines can include,but are not limited to, astemizole, cetirizine, ebastine, fexofenadine,loratidine, terfenadine, and combinations thereof.

In some embodiments, expectorants can include, but are not limited to,ammonium chloride, guaifenesin, ipecac fluid extract, potassium iodideand combinations thereof. In some embodiments, mucolytics can include,but are not limited to, acetylcycsteine, ambroxol, bromhexine andcombinations thereof. In some embodiments, analgesic, antipyretic andanti-inflammatory agents can include, but are not limited to,acetaminophen, aspirin, diclofenac, diflunisal, etodolac, fenoprofen,flurbiprofen, ibuprofen, ketoprofen, ketorolac, nabumetone, naproxen,piroxicam, caffeine and mixtures thereof. In some embodiments, localanesthetics can include, but are not limited to, lidocaine, benzocaine,phenol, dyclonine, benzonotate and mixtures thereof.

In some embodiments nasal decongestants and ingredients that provide theperception of nasal clearing can be included. In some embodiments, nasaldecongestants can include but are not limited to phenylpropanolamine,pseudoephedrine, ephedrine, phenylephrine, oxymetazoline, andcombinations thereof. In some embodiments ingredients that provide aperception of nasal clearing can include but are not limited to menthol,camphor, borneol, ephedrine, eucalyptus oil, peppermint oil, methylsalicylate, bornyl acetate, lavender oil, wasabi extracts, horseradishextracts, and combinations thereof. In some embodiments, a perception ofnasal clearing can be provided by odoriferous essential oils, extractsfrom woods, confectionerys, flowers and other botanicals, resins, animalsecretions, and synthetic aromatic materials.

Coloring Ingredients

In some embodiments, one or more colors can be included. As classifiedby the United States Food, Drug, and Cosmetic Act (21 C.F.R. 73), colorscan include exempt from certification colors (sometimes referred to asnatural even though they can be synthetically manufactured) andcertified colors (sometimes referred to as artificial), or combinationsthereof. In some embodiments, exempt from certification or naturalcolors can include, but are not limited to annatto extract, (E160b),bixin, norbixin, astaxanthin, dehydrated beets (beet powder), beetrootred/betanin (E162), ultramarine blue, canthaxanthin (E161 g),cryptoxanthin (E161c), rubixanthin (E161d), violanxanthin (E161e),rhodoxanthin (E161f), caramel (E150(a-d)), β-apo-8′-carotenal (E160e),β-carotene (E160a), alpha carotene, gamma carotene, ethyl ester ofbeta-apo-8 carotenal (E160f), flavoxanthin (E161a), lutein (E161b),cochineal extract (E120); carmine (E132), carmoisine/azorubine (E122),sodium copper chlorophyllin (E141), chlorophyll (E140), toastedpartially defatted cooked cottonseed flour, ferrous gluconate, ferrouslactate, grape color extract, grape skin extract (enocianina),anthocyanins (E163), haematococcus algae meal, synthetic iron oxide,iron oxides and hydroxides (E172), fruit juice, vegetable juice, driedalgae meal, tagetes (Aztec marigold) meal and extract, carrot oil, cornendosperm oil, paprika, paprika oleoresin, phaffia yeast, riboflavin (E,101), saffron, titanium dioxide, turmeric (E100), turmeric oleoresin,amaranth (E123), capsanthin/capsorbin (E160c), lycopene (E 160d), andcombinations thereof.

In some embodiments, certified colors can include, but are not limitedto, FD&C blue #1, FD&C blue #2, FD&C green #3, FD&C red #3, FD&C red#40, FD &C yellow #5 and FD&C yellow #6, tartrazine (E102), quinolineyellow (E104), sunset yellow (E110), ponceau (E124), erythrosine (E127),patent blue V (E131), titanium dioxide (E171), aluminium (E173), silver(E174), gold (E175), pigment rubine/lithol rubine BK (E180), calciumcarbonate (E170), carbon black (E153), black PN/brilliant black BN(E151), green S/acid brilliant green BS (E142), and combinationsthereof. In some embodiments, certified colors can include FD&C aluminumlakes. These consist of the aluminum salts of FD&C dyes extended on aninsoluble substrate of alumina hydrate. Additionally, in someembodiments, certified colors can be included as calcium salts.

Multiple Agents

In some embodiments, a chewing gum composition may include two or moreingredients for which managed release from the chewing gum duringconsumption is desired. In some embodiments, the ingredients may beencapsulated or otherwise included separately in different deliverysystems. Alternatively, in some embodiments the ingredients may beencapsulated or otherwise included in the same delivery system. Asanother possibility, one or more of the ingredients may be free (e.g.,unencapsulated) while one or more other ingredients may be encapsulated.

A chewing gum composition may include a group of ingredients for whichmanaged release of the group during consumption of the chewing gumcomposition is desired. Groups of two or more ingredients for whichmanaged release from a chewing gum composition during consumptionthereof may be desired include, but are not limited to: color andflavor, multiple flavors, multiple colors, cooling agent and flavor,warming agent and flavor, cooling agent and warming agent, cooling agentand high intensity sweetener, warming agent and high intensitysweetener, multiple cooling agents (e.g., WS-3 and WS-23, WS-3 andmenthyl succinate), menthol and one or more cooling agents, menthol andone or more warming agents, multiple warming agents, high intensitysweetener(s) and tooth whitening active(s), high intensity sweetener(s)and breath freshening active(s), an ingredient with some bitterness anda bitterness suppressor for the ingredient, multiple high intensitysweeteners (e.g., ace-k and aspartame, multiple tooth whitening actives(e.g., an abrasive ingredient and an antimicrobial ingredient, aperoxide and a nitrate, a warming agent and a polyol, a cooling agentand a polyol, multiple polyols, a warming agent and micronutrient, acooling agent and a micronutrient, a warming agent and a mouthmoistening agent, a cooling agent and a mouth moistening agent, awarming agent and a throat care agent, a cooling agent and a throat careagent, a warming agent and a food acid, a cooling agent and food acid, awarming agent and an emulsifier/surfactant, a cooling agent and anemulsifier/surfactant, a warming agent and a color, a cooling agent anda color, a warming agent and a flavor potentiator, a cooling agent and aflavor potentiator, a warming agent with sweetness potentiator, acooling agent with a sweetness potentiator, a warming agent and anappetite suppressant, a cooling agent and an appetite suppressant, ahigh intensity sweetener and a flavor, a cooling agent and a teethwhitening agent, a warming agent and a teeth whitening agent, a warmingagent and breath freshening agent, a cooling agent and a breathfreshening agent, a cooling agent and an effervescing system, a warmingagent and an effervescing system, a warming agent and an antimicrobialagent, a cooling agent and an antimicrobial agent, multiple anticalculusingredients, multiple remineralization ingredients, multiplesurfactants, remineralization ingredients with demineralizationingredients, acidic ingredients with acid buffering ingredients,anticalculus ingredients with antibacterial ingredients,remineralization ingredients with anticalculus ingredients, anticalculusingredients with remineralization ingredients with antibacterialingredients, surfactant ingredients with anticalculus ingredients,surfactant ingredients with antibacterial ingredients, surfactantingredients with remineralization ingredients, surfactants withanticalculus ingredients with antibacterial ingredients, multiple typesof vitamins or minerals, multiple micronutrients, multiple acids,multiple antimicrobial ingredients, multiple breath fresheningingredients, breath freshening ingredients and antimicrobialingredients, multiple appetite suppressors, acids and bases that reactto effervesce, a bitter compound with a high intensity sweetener, acooling agent and an appetite suppressant, a warming agent and anappetite suppressant, a high intensity sweetener and an appetitesuppressant, a high intensity sweetener with an acid, a probioticingredient and a prebiotic ingredient, a vitamin and a mineral, ametabolic enhancement ingredient with a macronutrient, a metabolicenhancement ingredient with a micronutrient, an enzyme with a substrate,a high intensity sweetener with a sweetness potentiator, a coolingcompound with a cooling potentiator, a flavor with a flavor potentiator,a warming compound with a warming potentiator, a flavor with salt, ahigh intensity sweetener with salt, an acid with salt, a coolingcompound with salt, a warming compound with salt, a flavor with asurfactant, an astringent compound with an ingredient to provide asensation of hydration, etc. In some embodiments, the multipleingredients may be part of the same delivery system or may be part ofdifferent delivery systems. Different delivery systems may use the sameor different encapsulating materials.

Typically, encapsulation of the multiple ingredients will result in adelay in the release of the predominant amount of the multipleingredients during consumption of a chewing gum composition thatincludes the encapsulated multiple ingredients (e.g., as part of adelivery system added as an ingredient to the chewing gum). This may beparticularly helpful in situations wherein separate encapsulation of theingredients may cause them to release with different release profiles.For example, different high intensity sweeteners may have differentrelease profiles because they have different water solubilities ordifferences in other characteristics. Encapsulating them together maycause them to release more simultaneously.

In some embodiments, the release profile of the multiple ingredients canbe managed for a gum by man aging various characteristics of themultiple ingredients, the delivery system containing the multipleingredients, and/or the chewing gum containing the delivery systemand/or how the delivery system is made in a manner as previouslydiscussed above.

The additional components, as described above, may be used in one ormore regions or layers of the gum composition, such as in the firstregion composition, the second region or the coating as desired.

The additional components may be added to one or more regions or layersof the multi-region gum in their encapsulated and/or unencapsulatedforms, as well as in combination with any of the other optionalcomponents. For instance, a single component may be added to amulti-region gum in its encapsulated and unencapsulated forms. The twodifferent forms of the component may be added to the same or differentregion of the multi-region gum in the same or different amounts.

In some embodiments, a single component may be added in two or moredifferent encapsulated forms. In particular, two or more differentencapsulating materials, such as different polymers, may be used toencapsulate two or more separate portions of the component. Thedifferent encapsulated forms of the same component may be added to thesame or different region of the multi-region gum product in the same ordifferent amounts. Further, in some embodiments, an unencapsulated formof the same component may be added in combination with the two or moredifferent encapsulated forms. The unencapsulated form of the componentmay be added to any region of the multi-region gum product in the sameor different amount from the encapsulated forms. Moreover, someembodiments may add an unencapsulated form of a similar component incombination with the two or more different encapsulated forms. Forinstance, two encapsulated forms of a single sweetener may be used incombination with an unencapsulated form of a different sweetener.

In some embodiments, combinations of two or more different componentsmay be employed. In some embodiments, at least one of the differentcomponents may be encapsulated, while at least one of the othercomponents of the combination may be unencapsulated. The multiplecomponents may be of the same type, e.g., two different sweeteners.Alternatively, the multiple components may be from distinctly differentcategories, e.g., a sweetener and a warming agent. The differentcomponents may be added to the same or different regions of themulti-region gum in the same or different amounts. The amounts of thecomponent in a particular region may be selected depending on how thecomponents may be perceived by the consumer in the different regions,the sensory experience or functional benefit desired to give to theconsumer, regulatory issues, resulting bad taste if too much is used inany one region, etc.

Some embodiments may include multiple components each of which isencapsulated. The multiple encapsulated components may be included inthe same or different regions of the gum in the same or differentamounts. The multiple encapsulated components may be the same type ofcomponent or from distinctly different categories.

In some embodiments in which multiple encapsulated components are addedto the multi-region gum composition, the multiple components may beencapsulated together or separately. In embodiments in which themultiple components are encapsulated together, the components may bemixed together and encapsulated by a single encapsulating material. Inembodiments in which the multiple components are encapsulatedseparately, the material used to encapsulate the components may be thesame or different.

The features and advantages of the present invention are more fullyshown by the following examples which are provided for purposes ofillustration, and are not to be construed as limiting the invention inany way.

EXAMPLES

The following examples are directed to multi-region chewing gumcompositions of some embodiments of the present invention. The second,or gum, region of the chewing gum compositions includes isomalt asdescribed herein.

Examples A-H

Center-fill chewing gum pieces in the form of pellets including isomaltin the gum region were prepared in accordance with the formulationsindicated in Tables 1 and 2 below. TABLE 1 Gum Region Composition % byWeight Component A B C D E F G H Gum Base* 28-42 28-42 28-42 28-42 28-4228-42 28-42 28-42 Lecithin 0.6 0.5 0.55 0.05 0.4 0.6 0.55 0.35 Isomalt50 39-49 30-55 40-52 20-60 40-60 20-40 37-52 Sorbitol 0 0-10 0-20  5-1020-60 0-5 20-40 0-5 Glycerin 0 0 0 0 0-5 0-5 0-3  5-10 Maltitol Syrup 56 4 3 0-8 0-8  0-10  3-10 (Lycasin ®) Flavors 2.5 2.5 2 2.5 3 3 2.8 2-3Cooling Agent 0.05 0.08 0.08 0 0.17 0.07 0.1   0-0.08 Acidulants 0-2 0-20-2 0-2 0-2 0-2 0-2 0-2 Intense Sweetener 2-4 2-4 2-4 2-4 2-4 2-4 2-42-4*gum base may include 3% to 11% by weight of a filler such as, forexample talc, dicalcium phosphate, and calcium carbonate (the amount offiller in the gum base is based on the weight percent of the gum regioncomposition, for example, in the above compositions A-H, if a gum regioncomposition includes 5% filler, the amount of gum base will be 5% lessthan the range recited in the table, i.e., from 23-37%)

TABLE 2 Liquid-Fill Composition % by Weight Component A B C D E F G HGlycerin 0   0-5 0-5  0-10 50   20-50 50 30-45 Maltitol Syrup  0-80 0-80 50-70 55-70 35-50 40-60 35-55 30-45 (Lycasin ®) Non-Crystallizing 0-30 0   20-30 25-30 0   0-15  0 30-45 Sorbitol Solution SodiumCarboxvmethyl- 0.1 0.1 0   0.1 0.2 0.1  0 0.1 cellulose (CMC) XanthanGum   0-0.2   0-0.2 0.2   0-0.2 0   0.1   0-0.2   0-0.15 Color   0-0.02  0-0.02   0-0.02   0-0.02   0-0.02   0-0.02   0-0.02   0-0.02 Flavors0.5-4   0.05-3   0.05-3   0.05-3   0.05-3   0.05-3   0.05-3   0.05-3  Cooling Agent 0.05-0.2  0.05-0.2  0.05-0.2  0.05-0.2  0.05-0.2 0.05-0.2  0.05-0.2  0.05-0.2  Acidulants 0-4 0-5 0-5 0-4 0-5 0-5 0-5 0-3Intense Sweetener 0.01-0.03 0.01-0.03 0.01-0.03 0.01-0.03 0.01-0.030.01-0.03 0.01-0.03 0.01-0.03

Gum pieces including three regions: liquid fill, gum region and coatingwere prepared according to the compositions in Tables 1 and 2 above witheach region according to the corresponding components for compositionsA-H.

The compositions for the gum regions were prepared by heating the gumbase to about 85° C. The gum base was then mixed with the isomalt,lecithin, glycerin and other polyols for six minutes. The isomaltemployed in the gum regions had a particle size of about 37 microns anda surface area of about 0.5 m²/g. In some of the formulations, sorbitolalso was included in combination with the isomalt. The sorbitol includedin such formulations had a particle size of about 225 microns and asurface area of about 1.12 m²/g. The flavor blends which include apre-mix of the flavors and cooling agents were added and mixed for 1minute. Finally, the acids and intense sweeteners were added and mixedfor 5 minutes. These mixing times are approximate and the mixture can bemixed longer as necessary.

The liquid fill composition was then prepared by first preparing apre-mix of the sodium carboxymethyl cellulose, glycerin, xanthan gum andpolyols. This pre-mix was then combined with the colors, flavors,cooling agents, acids and intense sweeteners and mixed.

The gum region and liquid-fill compositions were then extruded togetherand formed into pieces, which were then coated, by the process describedabove at paragraphs [0041] to [0045]. The gum pieces each had a totalweight of approximately 2.2 g. In the final gum pieces, the gum regionwas about 50-75% by weight, the liquid-fill was about 5-15% by weight,and the coating was about 25-35% by weight.

Gum pieces that were prepared by compositions A-H demonstrated goodstability and machinability. Performance data is provided in Table 3below for three different types of center-fill chewing gum piecesprepared in accordance with compositions A-H. TABLE 3 FormulationPerformance Data Polyol(s) Average Surface % Polyol A_(w) Gum in GumParticle Size Area Syrup Added Region A_(w) CF Region Ratio (mm) (m²/gr)(Gum Region) (initial) (initial) Stability Shrinkage ObservationsIsomalt 1 37 0.5 5% NA 0.72 +52 weeks 10% Good (solid trend)Machinability Isomalt/ 4:1 Isomalt Isomalt 4% NA 0.44 Progressing  5%Excellent Sorbitol (37) (0.5) well Machinability Sorbitol Sorbitol (225)(1.12) Isomalt 1 37 0.5 1% 0.18 0.68 Stable at — Ok 4 weeks

As seen in Table 3 above, the chewing gum pieces containing isomalt inthe gum region exhibited good shelf-life stability without evidence ofthe center-fill composition being absorbed into the gum region. Ingeneral, the chewing gum pieces exhibited low levels of shrinkage, whichprovides dimensional stability, and good seal integrity in the machinedgum pieces.

1. A multi-region chewing gum composition comprising: (a) a first regioncomposition; and (b) a second region composition adjacent to said firstregion composition, said second region composition comprising anelastomer and a polyol composition comprising isomalt alone or incombination with at least a second polyol.
 2. The chewing gumcomposition of claim 1, wherein said first region composition is acenter-fill composition and said second region composition is a chewinggum region surrounding said center-fill composition.
 3. The chewing gumcomposition of claim 1, wherein said isomalt is present in amounts ofabout 60% to about 100% by weight of said polyol composition.
 4. Thechewing gum composition of claim 1, wherein said isomalt has a particlesize of about 15 to about 100 microns.
 5. The chewing gum composition ofclaim 1, wherein said isomalt has a particle size of about 15 to about70 microns.
 6. The chewing gum composition of claim 1, wherein saidisomalt has a particle size of about 20 to about 50 microns.
 7. Thechewing gum composition of claim 1, wherein said second polyol comprisessorbitol.
 8. The chewing gum composition of claim 7, wherein saidsorbitol is present in amounts of about 0% to about 50% by weight ofsaid polyol composition.
 9. The chewing gum composition of claim 1,wherein said polyol composition has a water solubility of less than 35%by weight at 30° C.
 10. The chewing gum composition of claim 1, whereinsaid second region further comprises a syrup selected from the groupconsisting of sugars, triacetin, lectithin, polyols, hydrogenated starchhydrolysates, sorbitol maltitol, glycerin, and combinations thereof. 11.The chewing gum composition of claim 10, wherein said syrup is presentin amounts of about 1% to about 15% by weight of said chewing gumcomposition.
 12. The chewing gum composition of claim 10, wherein saidpolyol composition is saturated by said syrup.
 13. The chewing gumcomposition of claim 10, wherein the ratio of said polyol composition tosaid syrup is about 15:1 to about 4:1.
 14. The chewing gum compositionof claim 10, wherein the ratio of said polyol composition to said syrupis about 8:1 to about 6:1.
 15. The chewing gum composition of claim 1,wherein said first region composition is selected from the groupconsisting of a liquid, a solid, a semi-solid and a gas.
 16. The chewinggum composition of claim 15, wherein said first region compositioncomprises multiple liquids.
 17. The chewing gum composition of claim 1,further comprising a coating surrounding at least a portion of saidsecond region composition.
 18. The chewing gum composition of claim 1,wherein said composition comprises a chewing gum piece weighing about1.2 g to about 1.6 g.
 19. The chewing gum composition of claim 1,wherein said composition comprises a chewing gum piece in the form of aslab.
 20. The chewing gum composition of claim 1, wherein saidcomposition comprises a chewing gum piece in the form of a pellet. 21.The chewing gum composition of claim 1, wherein said compositioncomprises a chewing gum piece in the form of a multi-layer slab orstick.
 22. The chewing gum composition of claim 21, wherein said firstregion composition is positioned between two layers of said secondregion composition to form said multi-layer slab or stick.
 23. Acenter-fill chewing gum composition comprising: (a) a center-fillcomposition; and (b) a gum region composition surrounding saidcenter-fill composition, said gum region composition comprising a gumbase and a polyol composition comprising isomalt alone or in combinationwith at least a second polyol.
 24. A center-fill chewing gum compositioncomprising: (a) a liquid center-fill composition; and (b) a gum regionsurrounding said center-fill composition, said gum region comprising anelastomer and a polyol composition comprising isomalt in amounts ofabout 75% to about 100% by weight of said polyol composition andsorbitol in amounts of about 0% to about 25% by weight of said polyolcomposition.
 25. The chewing gum composition of claim 24, wherein theratio of said isomalt to said sorbitol is about 3:2 to about 4:1. 26.The chewing gum composition of claim 24, wherein said isomalt has aparticle size of about 20 to about 50 microns and said sorbitol has aparticle size of about 200 to about 250 microns.
 27. A method ofpreparing a multi-region chewing gum composition, comprising the stepsof: (a) extruding a multi-region composition comprising a first regioncomposition and a second region composition adjacent to said firstregion composition, said second region composition comprising: (i) anelastomer; and (ii) a polyol composition comprising isomalt alone or incombination with at least a second polyol; (b) sizing said multi-regioncomposition; (c) feeding said multi-region composition into a formingmechanism; (d) forming individual pieces of said multi-regioncomposition; and (e) coating said individual pieces with a coating. 28.The method of claim 27, further comprising the step of cooling saidmulti-region composition of step (b) prior to feeding said multi-regioncomposition into the forming mechanism.
 29. The method of claim 27,further comprising the step of cooling said individual pieces of saidmulti-region composition of step (d) prior to coating said individualpieces with a coating.